| 扩张型心肌病细胞因子及糖皮质激素受体的研究 |
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| 引用本文： | 董波,朱兴雷,潘祥林,赵以强,范祖森,潘景韬,黄定九. 扩张型心肌病细胞因子及糖皮质激素受体的研究[J]. 现代免疫学, 2002, 22(1): 34-35,41 |
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| 作者姓名： | 董波 朱兴雷 潘祥林 赵以强 范祖森 潘景韬 黄定九 |
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| 作者单位： | 1. 上海第二医科大学附属仁济医院心内实验室,上海,200001
2. 山东医科大学,济南,250010 |
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| 基金项目： | 山东省自然科学基金资助项目 ( 96 3 85 1) |
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| 摘 要： | 检测 30例扩张型心肌病 (DCM )外周血白细胞介素 1(IL 1)、白细胞介素 6 (IL 6 )及肿瘤坏死因子 (TNF α )的水平 ,并同时测定白细胞糖皮质激素受体 (GR )的水平 ,结果发现DCM患者的IL 1、IL 6及TNF α明显高于对照组 (P <0 0 1) ,而GR明显低于对照组 (P <0 0 1) ,表明DCM存在细胞因子及GR异常 ,并对其意义进行了分析。
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| 关 键 词： | 扩张性心肌病 受体 细胞因子 |
| 文章编号： | 1001-2478(2002)01-0034-02 |
Study on Cytokines and Glucocorticoid Receptors in Dilated Cardiomyopathy |
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| DONG Bo ,ZHU Xing-lei ,PAN Xiang-lin ,ZHAO Yi-qiang ,FAN Zu-sen ,PAN Jing-tao ,HUANG Ding-jiu. Study on Cytokines and Glucocorticoid Receptors in Dilated Cardiomyopathy[J]. Current Immunology, 2002, 22(1): 34-35,41 |
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| Authors: | DONG Bo ZHU Xing-lei PAN Xiang-lin ZHAO Yi-qiang FAN Zu-sen PAN Jing-tao HUANG Ding-jiu |
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| Affiliation: | DONG Bo 1,ZHU Xing-lei 2,PAN Xiang-lin 2,ZHAO Yi-qiang 2,FAN Zu-sen 2,PAN Jing-tao 2,HUANG Ding-jiu 1 |
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| Abstract: | To evaluate the levels and significance of circulating interleukin-1(IL-1)?interleukin-6(IL-6) and tumor necrosis factor(TNF) as well as the glucocorticoid receptors(GR) on blood leu kocytes in patients with dilated cardiomyopathy(DCM),the serum levels of IL-1, IL-6 and TNF were measured by using thymocyte proliferation methods,MTT chromatography and ELISA methods and the GR level was measured by radioimmunoassay. It showed that the levels of IL-1,IL-6 and TNF-α levels were significantly higher in DCM than in normal groups(NC,P<0.01),while the levels of GR in DCM was significantly lower than that in NC(P<0.01). These results suggest that the aberrant IL-1,IL-6,TNF and GR may take part in the pathogenesis of DCM. |
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| Keywords: | cardiomyopathy cytokine receptor |
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