COX-2和p53在乳腺癌组织中的表达及其相关性

目的:研究乳腺癌中环氧化酶-2(cy-clooxygenase-2,COX-2)和p53的表达及其相关性。方法:采用免疫组织化学法检测48例乳腺癌组织中COX-2与p53的表达情况,分析其相互间关系及与乳腺癌临床病理学特征间的联系。结果:乳腺癌中COX-2表达阳性率60·4%(29/48)。COX-2高表达与肿块>2cm、淋巴结转移阳性、ER阴性、PR阴性显著相关,而与患者年龄、肿瘤病理类型及肿瘤分期无明显关系。在p53阳性的乳腺癌患者中COX-2表达阳性率82·6%(19/23),而p53阴性的乳腺癌患者中,COX-2表达阳性率只有40·0%(10/25),两者相比有统计学意义,P=0·006。结论:COX-2在乳腺癌中高水平表达且与p53密切相关,提示乳腺癌中COX-2与p53存在互相调控机制,共同促进肿瘤的发生和发展。

Expression and correlation of COX-2 and p53 in human breast cancer

OBJECTIVE:To investigate the expression and correlation of cyclooxygenase (COX-2) and p53 in human breast cancer. METHODS: Forty-eight cases of breast cancer were detected by immunohistochemistry for the expressions of COX-2 and p53 and the relationship between COX-2 and p53 was analyzed together with the clinicopathologic characteristics. RESULTS: COX-2 was expressed in 60.4% of the breast cancer and the over expression correlated with the factors such as tumor larger than 2cm, lymph node mestastasis, negative ER and PR, and had no relations with the age, the pathologic type and the TNM stage.The expression rate of COX-2 in p53 positive breast cancers was 82.6%, significantly higher than that in p53 negative breast cancers, which is only 40%(10/25). CONCLUSION: The expression of COX-2 is significantly related to the expression of p53, which indicates that COX-2 and p53 can regulate each other and induce the tumorigenesis and development together.