布托啡诺复合芬太尼在口腔颌面部手术术后镇痛中的应用

目的观察静脉酒石酸布托啡诺复合芬太尼在口腔颌面部手术术后镇痛的临床效果及不良反应。方法ASAⅠ～Ⅱ级75例择期行口腔颌面部手术病人，随机分成三组，每组25例。A组：单独的酒石酸布托啡诺8mg加生理盐水共120ml；B组：单独的枸橼芬太尼0．8mg加生理盐水共120ml；C组：枸橼酸芬太尼0．4mg与酒石酸布托啡诺4mg加生理盐水共120ml；术毕给予负荷剂量4ml后连接镇痛泵进行自控镇痛（PCIA），术后分别记录6h、24h、48h三个时段的视觉模拟评分（VAS）并观察各种不良反应的发生情况。结果B组与C组VAS评分显著低于A组（P〈0．05），A组与C组不良反应发生率明显少于B组（P〈0．05）。结论枸橼酸芬太尼0．4mg与酒石酸布托啡诺4mg加生理盐水共120ml（C组）镇痛效果确切，不良反应较少，是口腔颌面部手术术后静脉镇痛治疗的良好选择之一。

Postoperative analgesia with intravenous hutorphanol tartratc combine with fentanyl for oral and maxillofacial region surgery

Objective To observe the postoperative analgesia effects and adverse reaction of the intrave-nous butorphanol tartrate combine with fentanyl for oral and maxillofacial surgery. Method ASA Ⅰ-Ⅱ Level 75 patients, selected for the oral and maxillofacial surgery, were divided into 3 groups randomly. Group A intravenous injected only 8mg butorphanol tratrate with physiological saline 120ml, Group B injected 0.8mg fentanyl citrate with physiological saline 120ml and group C injected 0.4mg fentanyl Citrate and 4rag butorphauol tartrate together with physiological saline 120ml. After operation, they were given loading dose 4ml, and then connected to analgesic pump for patient controlled analgesia (PCIA). The visual analogue scale (VAS) and adverse reaction of drugs was recorded 6h, 24h and 48h later. Results The VAS of group B and C are lower than that of group A obviously (P<0.05). The adverse reaction in group A and group C is distinctly less than that in group B (P<0.05). Conclusion The analgesic effect of 0.4mg Fentanyl Citrate and 4mg Butorphanol Tartrate together with physiological saline 120ml is obviously, and the adverse reaction is less. It is one of the good choices for intravenous analgesic treatment after oral and maxilllofacial surgery.