Helicobacter pylori infection enhances mucosal interleukin-1β, interleukin-6, and the soluble receptor of interleukin-2 |
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Authors: | D Basso M Scrigner A Toma F Navaglia F Di Mario M Rugge M Plebani |
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Institution: | (1) Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128 Padua, Italy;(2) Cattedra di Gastroenterologica, Universita' degli Studi di Padova, Padua, Italy;(3) Cattedra di Istochimica & Immunoistochimica Patologica, Universita degli Studi di Padova, Padua, Italy |
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Abstract: | It is thought thatHelicobacter pylori colonization of the gastric mucosa might stimulate the production of several cytokines, which might trigger and maintain
the gastric inflammation associated withHelicobacter pylori infection. In the present study we evaluated interleukin-1β, interleukin-6, and the soluble receptor of interleukin-2 both
in mucosal homogenates and in the sera ofHelicobacter pylori-infected (39 cases) and uninfected (40 cases) patients to investigate whether there was any relationship between variations
in cytokines and (1) the severity ofHelicobacter pylori-associated gastritis or (2) CagA-positiveHelicobacter pylori strains. Mucosal, but not serum levels of interleukins-1 and-6 and interleukin-2 receptor were significantly higher in infected
than uninfected patients, Serum levels ofHelicobacter pylori antibodies were significantly higher in infected than uninfected patients, These levels correlated with mucosal interleukin-1β.
The degree of antral or body inflammatory grade was higher in infected than in uninfected patients; cytokines levels were
higher in patients with high-grade gastritis, most of whom wereHelicobacter pylori positive. Patients infected with CagA-positive strains also had higher levels of interleukin-1β, but not of interleukin-2
receptor or interleukin-6. In conclusion,Helicobacter pylori infection results in a local increase in interleukins-1β and-6 and interleukin-2 receptor associated with high-grade mucosal
inflammation. Interleukin-1β seems to favor anti-Helicobacter pylori antibody production, and mucosal levels are enhanced mainly in patients infected with cytotoxicHelicobacter pylori strains. |
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Keywords: | Helicobacter pylori Interleukin-1β Interleukin-6 Interleukin-2 soluble receptor CagA |
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