| 蝙蝠葛酚性碱对BxPC-3荷瘤小鼠细胞凋亡基因p53表达的影响 |
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| 引用本文： | 尹蕊,苏慧,邵成文,孟丹,李环,苏云明. 蝙蝠葛酚性碱对BxPC-3荷瘤小鼠细胞凋亡基因p53表达的影响[J]. 中医药学报, 2009, 37(6) |
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| 作者姓名： | 尹蕊 苏慧 邵成文 孟丹 李环 苏云明 |
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| 作者单位： | 黑龙江中医药大学,黑龙江,哈尔滨,150040 |
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| 基金项目： | 2007黑龙江省自然科学基金课题 |
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| 摘 要： | 目的:观察蝙蝠葛酚性碱(PAMD)的抗肿瘤作用并进一步探讨其作用机制。方法:通过实时定量PCR(Real-time PCR)技术观察PAMD对胰腺癌细胞株BxPC-3皮下异位移植瘤细胞凋亡相关基因p53mRNA表达的影响,以此探讨PAMD抗肿瘤作用机理。结果:PAMD能够显著降低胰腺癌细胞株BxPC-3裸鼠皮下异位移植瘤组织中p53 mRNA表达量。结论:PAMD对胰腺癌细胞株BxPC-3裸鼠皮下异位移植瘤表现出明显抑制作用,能够有效的抑制肿瘤生长,其机理可能与凋亡相关基因表达有关。
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| 关 键 词： | 蝙蝠葛酚性碱 荷瘤小鼠 p53 |
Effect of PAMD on Bxpc-3 Tumor-bearing Mice Cell Apoptosis Gene p53 Expression |
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| YIN Rui,SU Hui,SHAO Cheng-wen,MENG Dan,LI Huan,SU Yun-ming. Effect of PAMD on Bxpc-3 Tumor-bearing Mice Cell Apoptosis Gene p53 Expression[J]. Acta Chinese Medicine and Pharmacology, 2009, 37(6) |
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| Authors: | YIN Rui SU Hui SHAO Cheng-wen MENG Dan LI Huan SU Yun-ming |
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| Affiliation: | YIN Rui; SU Hui; SHAO Cheng-wen; MENG Dan; LI Huan; SU Yun-mingHeilingjiang University of Chinese Medicine; Harbin 150040; Chin; |
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| Abstract: | Objective:To study and explore the anti-tumor effects and the further mechanism of phenolic alkaloids from Menispermum dauricum(PAMD)on subcutaneously heterotopic transplantation tumor in nude mouse from pancreatic carcinoma cell BXPC-3.Methods:Real-time polymerase chain reaction were used to observe the mRNA expression of apoptotic related gene p53.Results:PAMD can efficiently decrease the expressions of p53 mRNA on subcutaneously heterotopic transplantation tumor from pancreatic carcinoma cell BXPC-3.Conc... |
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| Keywords: | p53 |
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