单核细胞趋化蛋白-1在子宫内膜异位症患者血清及腹腔液中的变化

目的:检测子宫内膜异位症(EM)患者与正常妇女血清及腹腔液中单核细胞趋化蛋白-1(MCP-1)水平的异同,探讨其与子宫内膜异位症发病的关系。方法:子宫内膜异位症患者52名作为研究组,正常妇女45名作为对照组,采用双抗体夹心酶联免疫吸附技术(Sandw ichELISA)检测两组妇女血清及腹腔液中MCP-1水平。结果:血清MCP-1水平两组分别为:EM组(207±76)pg/m l,正常妇女组(148±56)pg/m l,两组间比较差别有极显著意义(P<0.01)。腹腔液MCP-1水平两组分别为:EM组(292土98)pg/m l,正常妇女组(164±65)pg/m l,两组间比较差别亦有极显著意义(P<0.01)。相关性分析发现:EM组血清与腹腔液MCP-1呈正相关(r=0.471,P=0.002),正常妇女组血清与腹腔液MCP-1无明显相关性。结论:EM患者血清与腹腔液MCP-1水平均显著升高,MCP-1是EM发生的关键因子之一。

Changes of monocyte chemoattractant protein - 1 levels in serum and abdominal cavity fluid in women with endometriosis

Objective:To investigate the relationship of monocyte chemoattractant protein-l(MCP-1) to endometriosis(EM).Methods:Levels of MCP-1 in serum and in abdominal cavity fluid were determined by a solid quantitative sandwich enzyme immunoassay technique(Sandwich ELISA) both in EM group and in controls,and relationship of MCP-1 levels in serum and in abdominal cavity fluid were analyzed.Results:Serum concentrations of MCP-l were increasd(P<0.01) in EM group(207±76) pg/ml than that of controls(148±56) pg/L.Concentrations of MCP-1 in abdominal cavity fluid were increasd(P<0.01) in EM group(292± 98) pg/ml than that in controls(164±65) pg/ml.In EM,nonparametric correlations analysis demonstrated that concentrations of serum MCP-1 were positively correlated with those in abdominal cavity fluid(r=0.471,P=0.002),but such a correlation did not be found in controls.Conclusion:Serum levels of MCP-l in EM increase significantly and higher concentrations of MCP-1 may be partly responsible for EM in a special way.