Effects of carbamazepine on cerebrospinal fluid somatostatin |
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| Authors: | David R. Rubinow Robert M. Post Philip W. Gold James C. Ballenger Seymour Reichlin |
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| Affiliation: | (1) Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA;(2) Department of Behavioral Medicine and Psychiatry, University of South Carolina, Charleston, South Carolina, USA;(3) Endocrine Division, New England Medical Center, Boston, Massachusetts, USA |
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| Abstract: | This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticovulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to increase CSF somatostatin in a small number of patients. The potential mechanism and significance of the effects of carbamazepine on CSF somatostatin are discussed in relation to the psychotropic, anticonvulsant, and analgesic properties of carbamazepine. |
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| Keywords: | Carbamazepine Somatostatin Cerebrospinal fluid Affective illness |
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