孕晚期阴道无乳链球菌感染者、白介素-8水平及妊娠结局

目的:探讨妊娠晚期孕妇生殖道无乳链球菌(GBS)感染者阴道分泌物中白介素-8(IL-8)水平特点及妊娠结局。方法:选择2015年1月—2017年1月本院妇产科收治的孕晚期感染GBS患者105例为感染组,其中胎膜早破62例、无胎膜早破43例;IL-8<800ng/L 36例、≥800ng/L 69例;另选同期本院无生殖道感染孕晚期孕妇100例为正常组,检测孕妇阴道分泌物中IL-8水平,随访至分娩,统计不良妊娠结局发生情况。结果:阴道分泌物中IL-8水平感染组(1032.62±402.35 ng/L)高于对照组(35.51±52.69 ng/L),胎膜早破组IL-8(1235.62±529.37 ng/L)高于无胎膜早破组(739.92±319.07 ng/L)(均P<0.05)。感染组孕妇胎儿宫内发育迟缓、产褥感染、新生儿感染发生率高于对照组,胎膜早破组新生儿感染率高于无胎膜早破组(均P<0.05)。IL-8≥800 ng/L组新生儿感染发生率(24.2%)高于IL-8<800 ng/L组(5.6%)(P<0.05)。结论:孕晚期生殖道GBS感染孕妇阴道分泌物IL-8水平显著增高,IL-8水平可能与GBS孕妇胎膜早破、新生儿感染有关。检测阴道分泌物IL-8水平有助于预测妊娠期孕妇生殖道GBS感染,预防异常妊娠结局发生。

Relationship between vaginal secretion interleukin-8 level of pregnant women with genital tract infection by no streptococcus lactis and their pregnancy outcomes

Objective:To investigate the characteristics of vaginal secretion interleukin-8(IL-8)level of pregnant women with genital tract infection by no streptococcus lactis,and its relationship with pregnancy outcomes.Methods:105 pregnant women with genital infection by tract no streptococcus lactis were selected in study group,which included 62 women with premature rupture and 43 women without premature rupture of membrane,and included 36 women with IL-8 level<800ng/L and 69 women with IL-8 level≥800 ng/L.And other 100 normal pregnant women were selected in control group.The vaginal secretion IL-8 levels of all included women were detected and followed up to delivery.The adverse pregnancy outcomes of all women were counted.Results:The IL-8 level of women in study group was 1032.62±402.35 ng/L,which was significant higher than that(35.51±52.69 ng/L)of women in the control group(P<0.05).In study group,the level of IL-8 of women with premature rupture of membrane was 1235.62±529.37 ng/L,which was significant higher than that(739.92±319.07 ng/L)of women without premature rupture of membrane(P<0.05).The incidences of intrauterine growth retardation,puerperal infection of women and neonatal infection in the study group was significant higher than those in the control group(P<0.05).In study group,the neonatal infection rate of women with without premature rupture of membrane was significant higher than that of women without premature rupture of membrane(P<0.05).The neonatal infection rate of women with IL-8 level≥800 ng/L was 24.2%,which was significant higher than that(5.6%)of women with IL-8 level≥800 ng/L(P<0.05).Conclusion:The level of IL-8 in vaginal secretions of pregnant women with genital tract no streptococcus lactis infection is significantly increased during the third trimester pregnancy,and the vaginal secretion level of IL-8 is closely related to premature rupture of membranes and neonatal infection.Detection of vaginal secretions IL-8 level of preganant women can help predict the genital tract infection by no streptococcus lactis and help prevent abnormal pregnancy outcomes.