妊娠期肝内胆汁淤积症孕妇血清胆汁酸水平与围生儿预后的关系

目的　探讨妊娠期肝内胆汁淤积症 (ICP)孕妇血清胆汁酸水平与围生儿预后的关系。方法　将 95例ICP孕妇以血清胆汁酸 5 0 μmol/L为界分为A组 (<5 0 μmol/L)、B组 (≥ 5 0μmol/L) ,回顾性分析两组在早产、胎儿宫内发育迟缓 (IUGR)、死胎、羊水粪染、胎儿窘迫及新生儿预后等方面的差异 ,以及胎儿窘迫、羊水粪染与临产的关系。结果　A组在早产、死胎、羊水粪染、胎儿窘迫以及新生儿窒息、畸形、转科等方面发生率比B组高 ,有显著性差异 (P <0 .0 5 ) ,但两组IUGR发生率无显著性差异 (P >0 .0 5 ) ,ICP孕妇临产后胎儿窘迫、羊水粪染率明显增高 ,有显著性差异 (P <0 .0 5 )。结论　血清胆汁酸水平是预测ICP孕妇胎儿宫内情况及其预后的一个重要指标 ,当血清胆汁酸≥ 5 0 μmol/L时 ,其围生儿预后较差

Correlation between serum total bile acid and perinatal infant prognosis in patients with intrahepatic cholestasis of pregnancy

Objective It is to study the correlation between the serum total bile acid and perinatal infant prognosis in patients with intrahepatic cholestasis of pregnancy (ICP).Methods Ninety-five patients with ICP were divided into group A (<50 μmol/L) and group B (≥50 μmol/L). The difference of premature delivery, intrauterine growth retardation (IUGR), fetal death, meconium-stained amniotic fluid, fetal distress, neonatal prognosis and the relation between fetal distress, meconium-stained amniotic fluid and in labor of the two groups were analyzed retrospectively.Results The rates of premature delivery, fetal death, meconium-stained amniotic fluid, fetal distress, neonatal asphyxia and neonatal abnormality in group A were obviously higher than group B (P<0.05), the rate of IUGR was no significant difference between the two groups(P>0 05), the rates of fetal distress and meconium-stained amniotic fluid of patients with ICP after in labor were significant higher (P<0.05).Conclusion Serum total bile acid is one of the important indexes which is used to pretest the fetal condition in uterus and its prognosis of patients with ICP. Perinatal infant prognosis is poor when serum total bile acid ≥50 μmol/L.