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血清C肽浓度测定的临床意义探讨
引用本文:王国洪,许瑞吉,张中书,王筱劼. 血清C肽浓度测定的临床意义探讨[J]. 放射免疫学杂志, 2006, 19(1): 15-17
作者姓名:王国洪  许瑞吉  张中书  王筱劼
作者单位:南京军区南京总医院放免室,210002;南京军区南京总医院放免室,210002;南京军区南京总医院放免室,210002;南京军区南京总医院放免室,210002
摘    要:目的: 研究血清C肽浓度及胰岛素与C肽比值的临床意义。方法:用放射免疫分析测定2型糖尿病和肾功能不全患者血清C肽、胰岛素浓度,并计算胰岛素与C肽比值。结果:肾功能不全组病人血清C肽、胰岛素水平显著高于糖尿病各组,且胰岛素与C肽比值显著低于糖尿病各组(P〈0.01);在糖尿病各年龄组中,胰岛素水平无明显变化(P〉0.05);但血清C肽水平随年龄增大而升高,而胰岛素与C肽比值则显著下降(P〈0.01)。结论:测定血清C肽水平及胰岛素与C肽比值有助于了解糖尿病患者的肾功能状况,值得进一步深入探讨。

关 键 词:C-肽  糖尿病  胰岛素  肾功能不全
收稿时间:2005-10-19
修稿时间:2005-10-19

Clinical Significance of Determination of Serum C-peptide Levels
Wang Guohong, Xu Ruiji, Zhang Zhongshu,et al.. Clinical Significance of Determination of Serum C-peptide Levels[J]. Journal of Radioimmanology, 2006, 19(1): 15-17
Authors:Wang Guohong   Xu Ruiji   Zhang Zhongshu  et al.
Abstract:Objective To study the clinical meanings of changes of serum C-peptide levels and insulin/C-peptide ratio.Methods Serum insulin and C-peptide levels were determined with RIA in 171 patients with DM-2 of all ages(31-50,n=50,51-60,n=60,over 60,n=61) and 50 patients with renal insufficiency.The insulin/C-peptide ratio were calculated.Results The serum C-peptide and insulin levels in patients with renal insufficiency were significantly higher than those in diabetics of all age groups and the insulin/C-peptide ratio were significantly lower than those in diabetics(P<0.01).Among the diabetics,the serum insulin levels were about the same in the three age groups(P>0.05),but the serum C-peptide levels increased as the age of patients increased with decrease of insulin/C-peptide ratio(P<0.01).Conclusion Abnormal changes of C-peptide levels and insulin/C-peptide ratio in diabetics(the age-factor corrected) might reflect renal dysfunction.
Keywords:C-peptide(C-P)  diabetes mellitus(DM)  insulin(INS)  renal dysfunction
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