血清C肽浓度测定的临床意义探讨

目的： 研究血清C肽浓度及胰岛素与C肽比值的临床意义。方法：用放射免疫分析测定2型糖尿病和肾功能不全患者血清C肽、胰岛素浓度，并计算胰岛素与C肽比值。结果：肾功能不全组病人血清C肽、胰岛素水平显著高于糖尿病各组，且胰岛素与C肽比值显著低于糖尿病各组（P〈0．01）；在糖尿病各年龄组中，胰岛素水平无明显变化（P〉0．05）；但血清C肽水平随年龄增大而升高，而胰岛素与C肽比值则显著下降（P〈0．01）。结论：测定血清C肽水平及胰岛素与C肽比值有助于了解糖尿病患者的肾功能状况，值得进一步深入探讨。

Clinical Significance of Determination of Serum C-peptide Levels

Objective To study the clinical meanings of changes of serum C-peptide levels and insulin/C-peptide ratio.Methods Serum insulin and C-peptide levels were determined with RIA in 171 patients with DM-2 of all ages(31-50,n=50,51-60,n=60,over 60,n=61) and 50 patients with renal insufficiency.The insulin/C-peptide ratio were calculated.Results The serum C-peptide and insulin levels in patients with renal insufficiency were significantly higher than those in diabetics of all age groups and the insulin/C-peptide ratio were significantly lower than those in diabetics(P<0.01).Among the diabetics,the serum insulin levels were about the same in the three age groups(P>0.05),but the serum C-peptide levels increased as the age of patients increased with decrease of insulin/C-peptide ratio(P<0.01).Conclusion Abnormal changes of C-peptide levels and insulin/C-peptide ratio in diabetics(the age-factor corrected) might reflect renal dysfunction.