Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy |
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| Authors: | Kim Min Sun Choi Myoung Ae Choi Dong Ok Lee Moon Young Kim Kwang Yong Rhee Jeong Kyun Jin Yuan Zhe Park Byung Rim |
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| Affiliation: | Vestibulocochlear Research Center and Department of Physiology, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan 570-749, South Korea. |
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| Abstract: | The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 immunoreactivity decreased rapidly and was undetectable by 90 min after UL. These results suggest that unilateral deafferentation of the vestibular system triggers intracellular signal pathways that activate ERK 1/2 in the VN. |
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| Keywords: | Motor systems and sensorimotor integration Vestibular system |
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