湖南永州人群高血压病患者脑血管疾病的防治研究

目的观察从单纯的血压控制转移到降低脑血管疾病为治疗原则的高血压新疗法的临床效果。方法选取238例高血压病患者(基础收缩压为160mmHg以上),随机分为两组,治疗组123例持续的给予氨氯地平(5mg)加辛伐他汀(20mg),对照组115例给予氨氯地平(5mg)加安慰剂;观察两年内脑卒中的发生情况。结果两组的血压无显著性差异(P>0.05),两组的甘油三酯、总胆固醇、高密度脂蛋白和低密度脂蛋白之间均有显著性差异(P<0.05或<0.01);治疗组患者脑卒中发生率较对照组显著降低(P<0.01),两组的卒中病死率无显著性差异(P>0.05)。随着治疗时间的延长临床效果越显著。结论给予高血压患者氨氯地平控制血压联合他汀类药物降血脂能够更大幅度的降低脑卒中的发生风险。

The study of prevention and cure of cerebrovascular disease in patients with hypertension in Yongzhou city of Hunan province

Objective To observe the clinical effects of a new therapy principle from a simple blood pressure control transfer to reduce cerebrovascular disease for the patients with hypertension. Methods 238 patients with hypertension （based on more than 160 mmHg for systolic blood pressure）,were randomly divided into two groups, 123 cases of the treatment group continued taken amlodipine （5 mg） and simvastatin （20 mg） ,hut 115 cases in the control group applied amlodipine （5 mg） and placebo. The occurrence of stroke were observed within two years in two groups. Results There was no significant difference beween the treatment group and the control group on blood pressure （ P 〉0.05）, The triglycerides, total cholesterol, high density lipoprotein and low density lipoprotein between two groups were significantly different （ P 〈0.05 or 〈0.01）. The stroke incidence of the treatment group was significantly lower than the control group （ P 〈0.01）. Stroke mortality between two groups has no significant difference （ P 〉0.05）. The clinical effect increase with the extension of treatment time. Conclusion Amlodipine combined hypolipidemic statins can significantly reduce the risk of stroke in patients with high blood pressure.