The development of tolerance to morphine in the rat |
| |
Authors: | M. Fernandes S. Kluwe H. Coper |
| |
Affiliation: | (1) Institute for Neuropsychopharmacology, Free University Berlin, Ulmenallee 30, D-1000 Berlin 19 |
| |
Abstract: | Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semilogarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HCl tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests. |
| |
Keywords: | Morphine Tolerance Rats |
本文献已被 SpringerLink 等数据库收录! |
|