c-Fos,c-Jun与Bcl-2蛋白在胃癌组织中的表达及意义

Expression of c-Fos, c-Jun and Bcl-2 and their significances in gastric carcinoma

AIM:To detect the expression of c-Fos, c-Jun and Bcl-2 protein in gastric carcinoma and explore their correlations with the development and biological behavior of gastric carcinoma. METHODS: SABC immunohistochemistry was used to detect the expressions of c-Fos, c-Jun and Bcl-2 protein in specimens (n = 54) from gastric carcinoma and the corresponding cancer-adjacent tissues. The data were analyzed by Chi-Square test using SPSS software. RESULTS: The positive rates of c-Fos, c-Jun and Bcl-2 expression were significantly higher in cancer tissues than those in cancer-adjacent ones (68.5% vs 27.8%, X2= 17.95, P < 0.01; 63.0% vs 24.1%, X2 = 16.61, P < 0.01; 64.8% vs 25.9%, X2= 16.48, P < 0.01). The significant difference was present in the expression of c-Fos and c-Jun among different histological types (P = 0.018; P = 0.032), but wasn't among different status of re- gional lymph node metastasis and TNM stages. Bcl-2 expression was markedly different among different histological types, status of regional lymph node metastasis and TNM stages (P = 0.035; P = 0.032; P = 0.009). There was a positive correlation between expression of Bcl-2 and c-Fos (r = 0.336, 0.688, P < 0.05), Bcl-2 and c-Jun (r = 0.318, 0.512, P < 0.05) as well as between c-Fos and c-Jun (r = 0.719, 0.586, P < 0.001). CONCLUSION: The expression of c-Fos, c-Jun and Bcl-2 are closely correlated with the carcino-genesis, development, and histological types.