Kategorisierung der Tumoren der Cervix uteri |
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Authors: | S. F. Lax L.-C. Horn T. Löning |
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Affiliation: | 1.Institut für Pathologie, LKH Graz Süd-West, Standort West,Akademisches Lehrkrankenhaus der Medizinischen Universit?t Graz,Graz,?sterreich;2.Institut für Pathologie,Universit?tsklinikum Leipzig,Leipzig,Deutschland;3.Institut für Pathologie,Albertinenkrankenhaus,Hamburg,Deutschland |
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Abstract: | In the 2014 WHO classification, squamous cell precursor lesions are classified as low-grade and high-grade intraepithelial lesions. LSIL corresponds to CIN1, HSIL includes CIN2 and CIN3. Only adenocarcinoma in situ (AIS) is accepted as precursor of adenocarcinoma and includes the stratified mucin-producing intraepithelial lesion (SMILE). Although relatively rare, adenocarcinoma and squamous cell carcinoma can be mixed with a poorly differentiated neuroendocrine carcinoma. Most cervical adenocarcinomas are low grade and of endocervical type. Mucinous carcinomas show marked intra- and extracellular mucin production. Almost all squamous cell carcinomas, the vast majority of adenocarcinomas, and many rare carcinoma types are HPV related. For low grade endocervical adenocarcinomas, the pattern-based classification according to Silva should be reported. Neuroendocrine tumors are rare and are classified into low-grade and high-grade, whereby the term carcinoid is still used. |
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