Pathology type does not predict language lateralization in children with medically intractable epilepsy |
| |
| Authors: | Darren S. Kadis Elizabeth N. Kerr James T. Rutka O. Carter Snead III Shelly K. Weiss Mary Lou Smith |
| |
| Affiliation: | 1. Department of Psychology, University of Toronto, Toronto, Ontario, Canada;2. Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada;3. Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada;4. Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada;5. Department of Pediatrics, Division of Neurology, University of Toronto, Toronto, Ontario, Canada;6. Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada |
| |
| Abstract: | Purpose: We examined potential differences in the effects of pathology type on language lateralization in pediatric epilepsy. Methods: We examined findings from intracarotid sodium amobarbital procedure (IAP/Wada) in a large consecutive sample of children with refractory epilepsy. Subjects were assigned to one of three pathology groups: developmental (n = 28), acquired (n = 26), and tumor (n = 20); groups were compared for language lateralization. Results: Rates of atypical language lateralization did not differ across groups. Greater than half of the subjects with left hemisphere insults and seizure onset before 6 years of age had atypical language lateralization, independent of pathology type. Discussion: Atypical language lateralization may occur in the context of developmental, acquired, and/or tumor pathology. |
| |
| Keywords: | Intracarotid sodium amobarbital/Wada Plasticity Lesion Interhemispheric |
|
|
