| 抗痫灵对大鼠杏仁核点燃发展过程的影响 |
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| 引用本文： | 吴惠秋,平钎铣,金小南,周瑾,刘国卿.抗痫灵对大鼠杏仁核点燃发展过程的影响[J].中国药科大学学报,1990(1):59-61. |
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| 作者姓名： | 吴惠秋 平钎铣 金小南 周瑾 刘国卿 |
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| 作者单位： | 中国药科大学药理学教研室，中国药科大学药理学教研室，中国药科大学药理学教研室，中国药科大学药理学教研室，中国药科大学药理学教研室 1989届毕业生 |
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| 基金项目： | 国家自然科学基金，国家教委青年教师基金 |
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| 摘 要： | 抗痫灵(Antiepilepsirine,AE)是胡椒碱的衍生物。临床资料表明,AE的抗癲痫谱较广,尤其对大发作疗效较好,毒副作用小。在多种动物实验模型上都显示了较强的抗惊作
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| 关 键 词： | 癫痫 点燃模型 杏仁基底外侧核 刺激后放电 抗痫灵 |
EFFECT OF ANTIEPILEPSIRINE ON THE DEVELOPMENT OF AMYGDALA-KINDLING IN RAT |
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| Wu Huiqiu,Ping Hanxian,Jin Xiaonan,Zhou Jin,Liu Guoqing.EFFECT OF ANTIEPILEPSIRINE ON THE DEVELOPMENT OF AMYGDALA-KINDLING IN RAT[J].Journal of China Pharmaceutical University,1990(1):59-61. |
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| Authors: | Wu Huiqiu Ping Hanxian Jin Xiaonan Zhou Jin Liu Guoqing |
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| Institution: | Wu Huiqiu,Ping Hanxian,Jin Xiaonan,Zhou Jin,Liu Guoqing Department of Pharmacology |
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| Abstract: | The effect of antiepilepsirine, a derivative of piperine, on the development of rat amygdala kindling seizures was studied. An average of daily consecutive 15 stimulations was needed to reach the first stage 5 seizures at which the rats showed behavioral convulsions and elcctroencephalographic abnormalities. Chronic administration of antiepilepsirine at a daily dose of 85 mg/kg ip for consecutive 10 times 2h before standard stimulation siginifieantly doubled the stimulations needed to reach the first stage 5 seizures, while less affected the afterdischarge duration. The results demonstrate that antiepilepsirine has a pronounced prophylactic effect on the development of kindling seizures. |
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| Keywords: | Epilepsy Kindling model Basolateral amygdaloid Afterdischarge Antiepilepsirine |
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