三种常见抗真菌药口服治疗甲真菌病疗效观察

目的了解伊曲康唑、特比萘芬和氟康唑口服治疗甲真菌病的疗效。方法63例患者根据治疗药物的不同分为三组，伊曲康唑组41例，特比萘芬组13例，氟康唑组9例。分别在疗程结束后3个月和6个月时，进行真菌学检查和临床症状观察。结果伊曲康唑、特比萘芬和氟康唑治疗结束3个月和6个月的临床有效率分别为87．80％和92．68％、84．62％和92．31％、88．89％和88．89％；治疗结束3个月和6个月真菌学治愈率一致，分别为100％、92．31％和100％％。结论伊曲康唑与特比萘芬和氟康唑治疗甲真菌病均能取得较好的疗效。美扶因价格相对便宜，抗菌谱更广，具有更高的效价比。

Efficacy of three antifungal agents in treatment of onychomycosis

Objective To understand the efficacy of itraconazole with terbinafine and fluconazole in treatment of onychomycosis. Methods There 63 cases with onychomycosis were divided into Itraconazole Group, consisted of 41 cases and treated with itraconazole, Terbinafine Group consisted of 13 cases and treated with terbinafine, and Fluconazole Group consisted of 9 cases and treated with fluconazole. Then the efficacy of three antifungal agents were recorded three months and six months after treatment. Results Three months and six months after treatment , the effective rates of itraconazole, terbinafine and fluconazole group were 87.80% and 92.68%, 84.62% and 92.31%, 88.89% and 88.89%, respectively; and the fungal removal rates were 100%,92.31% and 100%% respectively. Conclusion Itraconazole, terbinafine and fluconazole is effective on onychomycosis.