| 阻塞性黄疸大白鼠肾脏前列环素与血栓素的改变 |
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| 引用本文： | 邢贻雷,方善德.阻塞性黄疸大白鼠肾脏前列环素与血栓素的改变[J].海南医学,1993,4(3):36-38. |
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| 作者姓名： | 邢贻雷 方善德 |
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| 作者单位： | 海南省人民医院 |
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| 摘 要： | 本实验用放免方法测定雄性Sprague-Dewley大白鼠分别在结扎胆管1、2、3和4周后肾皮质与髓质组织中6-keto-PGF_(1α)及TXB_2含量来了解肾皮质与髓质中前列环素和血栓素A_2的变化。结合表明,肾皮质与髓质中6-Keto-PGF_(1α)在胆管结扎早期(1～2周)显著升高,而后期(3—4周)无继续升高。肾皮质与髓质中的TXB_2在结扎胆管后期显著升高,引起6-keto-PGF_(1α)/TXB_2比值在胆管结扎后期显著降低。提示胆管梗阻时间越长,肾组织中TXA_2合成增加越明显,导致肾脏易于出现血管痉挛,血小板聚集,肾循环功能障碍。
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| 关 键 词： | 阻塞性黄疽 肾衰竭 前列环素 |
THE CHANGES OF THE RENAL PGI_2 AND TXA_2 IN OBSTRUCTIVE JAUNDICE RATS |
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| Xing Yi-lei,et al,Hainan Provincial People's Hospital.THE CHANGES OF THE RENAL PGI_2 AND TXA_2 IN OBSTRUCTIVE JAUNDICE RATS[J].Hainan Medical Journal,1993,4(3):36-38. |
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| Authors: | Xing Yi-lei Hainan Provincial People's Hospital |
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| Institution: | Xing Yi-lei,et al,Hainan Provincial People's Hospital,570011 |
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| Abstract: | The PGI2 ( as 6-keto-PGF1a ) and TXA2(as TXB2)in the kidneys in SD male rats their bile-ducts were ligated were detected by RIA method. The results showed that after the bile-ducts were ligated for a long time ( 2 to 4 weeks ) the sythesis of PGI2 in the kidneys was suppressed while the sythesis of TXA2 in the kidneys was increased. The longer the bile-ducts were obstructed, the higher the TXA2 was. The ratio of 6-keto-PGFla to TXB2 reduced significantly asthe bile-ducts were obstructed for a long time which made the kidneys be damaged easily owing to ischemia. |
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| Keywords: | Prostaglandins I2 Thromboxane A2 Ligation of bile ducts Kidney |
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