MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas |
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Authors: | Roehle Anja Hoefig Kai P Repsilber Dirk Thorns Christoph Ziepert Marita Wesche Kai O Thiere Marlen Loeffler Markus Klapper Wolfram Pfreundschuh Michael Matolcsy András Bernd Heinz-Wolfram Reiniger Lila Merz Hartmut Feller Alfred C |
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Affiliation: | Institute for Pathology, University Clinic Schleswig-Holstein, Campus Luebeck, Luebeck;, Research Institute for the Biology of Farm Animals FBN, Dummerstorf;, Institute for Medical Informatics, Statistics and Epidemiology IMISE, University Leipzig, Leipzig;, Institute for Pathology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel;, Department of Internal Medicine I, University Clinic Saarland, Homburg/Saar, Germany;, and 1st Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary |
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Abstract: | MicroRNAs (miRNA, miR) are negative regulators of gene expression that play an important role in diverse biological processes such as development, cell growth, apoptosis and haematopoiesis, suggesting their association with cancer. Here we analysed the expression signatures of 157 miRNAs in 58 diffuse large B-cell lymphoma (DLBCL), 46 follicular lymphoma (FL) and seven non-neoplastic lymph nodes (LN). Comparison of the possible combinations of DLBCL-, FL- and LN resulted in specific DLBCL- and FL-signatures, which include miRNAs with previously published function in haematopoiesis ( MIRN150 and MIRN155 ) or tumour development ( MIRN210 , MIRN10A , MIRN17-5P and MIRN145 ). As compared to LN, some miRNAs are differentially regulated in both lymphoma types ( MIRN155 , MIRN210 , MIRN106A , MIRN149 and MIRN139 ). Conversely, some miRNAs show lymphoma-specific aberrant expression, such as MIRN9/9* , MIRN301 , MIRN338 and MIRN213 in FL and MIRN150 , MIRN17-5P , MIRN145 , MIRN328 and others in DLBCL. A classification tree was computed using four miRNAs ( MIRN330 , MIRN17-5P , MIRN106a and MIRN210 ) to correctly identify 98% of all 111 cases that were analysed in this study. Finally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors ( MIRN21 , MIRN127 and MIRN34a ) and oncogenes ( MIRN195 and MIRNLET7G ). |
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Keywords: | microRNA lymphoma diffuse large B-cell lymphoma follicular lymphoma |
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