| 改性瓜尔胶微球用作蛋白药物载体的研究 |
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| 引用本文： | 欧富初,张黎明,陈汝福. 改性瓜尔胶微球用作蛋白药物载体的研究[J]. 生物医学工程学杂志, 2006, 23(6): 1267-1270 |
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| 作者姓名： | 欧富初 张黎明 陈汝福 |
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| 作者单位： | 1. 中山大学,化学与化学工程学院,高分子研究所,广州,510275
2. 中山大学,附属第二医院,肝胆外科,广州,510120 |
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| 基金项目： | 国家自然科学基金;国家高技术研究发展计划(863计划);广东省科技厅科技计划;广东省广州市科技攻关项目 |
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| 摘 要： | 利用含季铵基团瓜尔胶衍生物与三聚磷酸钠在溶液中的离子胶凝反应，在室温、不使用乳化剂或有机溶剂条件下，首次制得一种可生物降解改性瓜尔胶微球，其平均粒径约为140pm且其粒度分布较窄、近似为高斯分布；通过对不同浓度牛血清白蛋白模型药物的负载实验，发现其包封产率可超过80％；通过对载药微球体外释药行为的考察，发现牛血清白蛋白的持续释放时间可达6h以上且其释放百分率受其初始浓度和温度的影响。
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| 关 键 词： | 药物载体 微球 瓜尔胶 牛血清白蛋白 可控释放 |
| 收稿时间： | 2004-07-06 |
| 修稿时间： | 2004-07-062004-12-15 |
Study on Modified Guar Gum Microsphere as A Protein Drug Carrier |
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| Ou Fuchu,Zhang Liming,Chen Rufu. Study on Modified Guar Gum Microsphere as A Protein Drug Carrier[J]. Journal of biomedical engineering, 2006, 23(6): 1267-1270 |
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| Authors: | Ou Fuchu Zhang Liming Chen Rufu |
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| Affiliation: | 1,Institute of Polymer Science, School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, China;2,Department of Hepatobiliary Surgery, The Second Affiated Hospital of Zhongshan University, Guangzhou 510120, China |
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| Abstract: | A biodegradable modified guar gum microsphere was prepared for the first time by ionic gelation of the guar gum derivative containing quarternary ammonium group with tripolyphosphate at room temperature in the absence of emulsifying agent or organic solvent. Its average particle diameter was about 140 microm and the particle size had a narrow and normal gauss distribution. From the loading experiment of bovine serum album (BSA) with various concentrations, it was found that the encapsulation efficiency is more than 80%. By the investigation of in vitro release from the BSA-loaded microsphere, it was found that the BSA had a continuous release for more than 6 hours and the release percentage was affected by the initial concentration of the BSA and temperature. |
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| Keywords: | Drug carrier Microsphere Guar gum Bovine serum album Controlled release |
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