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Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients |
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| Authors: | Gallegos-Arreola M P Batista-González C M Delgado-Lamas J L Figuera L E Puebla-Pérez A M Arnaud-López L Peralta-Leal V Ramírez-Jirano L J Zúñiga-González G M |
| Affiliation: | División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco, México. marthaga@foreigner.class.udg.mx |
| Abstract: | We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients. Distributions of CYP1A1 Val/Val genotypes in peripheral blood DNA samples from 136 healthy controls and 136 adult patients with ALL were evaluated. There was an increased frequency of the CYP1A1 Val/Val genotype among ALL patients, showing a significant association between this genotype and the risk of developing ALL. |
| Keywords: | Polymorphism CYP1A1 Acute lymphoblastic leukemia Mexican population |
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