| 淡水微囊藻毒素毒理学研究进展 |
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| 引用本文： | 陈国永,杨振波,陶茂萱.淡水微囊藻毒素毒理学研究进展[J].卫生研究,2006,35(1):120-122. |
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| 作者姓名： | 陈国永 杨振波 陶茂萱 |
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| 作者单位： | 中国疾病预防控制中心环境与健康相关产品安全所,北京,100021 |
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| 基金项目： | 人事部留学回国人员科技活动择优基金 |
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| 摘 要： | 微囊藻毒素是由淡水蓝藻产生的一类具有肝毒性的生物活性物质。它能够抑制蛋白磷酸酶1和蛋白磷酸酶2A的活性,使细胞内的蛋白磷酸化和去磷酸化失衡。微囊藻毒素能够对人体产生一系列的危害,如肝毒性、肾毒性、肠毒性和促癌作用等。
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| 关 键 词： | 淡水藻华 微囊藻毒素 毒理学 |
| 文章编号： | 1000-8020（2006）01-0120-03 |
| 收稿时间： | 2005-03-28 |
| 修稿时间： | 2005年3月28日 |
Toxicological study of fresh water microcystins |
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| Chen Guo-yong,Yang Zhen-bo,Tao Mao-xuan.Toxicological study of fresh water microcystins[J].Journal of Hygiene Research,2006,35(1):120-122. |
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| Authors: | Chen Guo-yong Yang Zhen-bo Tao Mao-xuan |
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| Institution: | Institute for Environmental Health and Related Product Safety, China CDC, Beijing 100021, China |
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| Abstract: | Microcystins are a group of toxins that are produced by fresh water cyanobacteria. They are bioactive materials which are hepatotoxic. They can inhibit serine/threonine protein phosphatase (PP1 and PP2A), breaking the balance between protein phosporylation and phosphorylysis. They present a wide range of harmful effects to human body, such as hepatotoxicity and tumor promotion. They also affect other organs like kidney and intestines. Recently, more and more attention is being paid to microcystins worldwide. This review summarizes the progress in the toxicological study of fresh water microcystins. |
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| Keywords: | fresh water algal bloom micorcystins toxicology |
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