托吡酯合成工艺研究

目的 合成托吡酯并对工艺进行研究。方法 以D-果糖为起始原料，在浓硫酸的催化下，与丙酮缩合生成双丙酮果糖，再同氯磺酸异氰酸酯反应采用“一锅法”制备，得到托吡酯。结果 本工艺总收率为43.3%。结论 工艺改进后，简化了操作过程，提高了托吡酯的收率。

Synthesis of topiramate

Objective To synthesize topiramate and research the synthetic process. Methods Catalyzed by concentrated sulfuric acid, D-fructopyranose was used as the initial raw material, then condensation of D-fructopyranose with acetone to synthesize 2,3,4,5-bis-O-(1-methylethylidene)-D-fructopyranose. The topiramate was produced by reaction between 2,3,4,5-bis-O-(1- methylethylidene)-D-fructopyranose and chlorosulfonyl isocyanate via one pot method. Results The total yield by the synthetic process was 43.3%. Conclusion After the process improvement, the operating process is simplified and the yield of topiramate is improved.