脱蛋白牛松质骨结合自体红骨髓移植修复骨肿瘤性骨缺损:与自体骨移植材料为对照标准的效果比较

背景:对于骨肿瘤性骨缺损,以往多采用取自体髂骨移植修复。目的:以自体髂骨移植修复骨肿瘤或瘤样病变引起的腔洞性骨缺损为对照标准,观察脱蛋白牛松质骨结合自体红骨髓移植封闭残腔以及新生骨密度的情况。设计:随机分组设计、对照观察。单位:解放军第一七五医院骨科。对象:选择1993-07/1998-07解放军第一七五医院骨科收治骨缺损患者125例。随机分为实验组63例,患病时间(6.2±2.1)个月,骨缺损(136±30)mm3。对照组62例,患病时间(6.1±2.3)个月,骨缺损(133±37)mm3。方法:实验组接受脱蛋白牛松质骨结合自体红骨髓移植治疗,对照组接受自体髂骨移植治疗。首先彻底刮除肿瘤组织,用体积分数为0.95的乙醇烧灼创面后,再刮除烧灼面致出血,然后植入骨移植材料,植入的骨量要充足、紧密。以术后第1周的X射线片作为新骨生长的密度对比标准,术后第3,6,8个月分别摄X射线片,以术后8个月指标为两组比较标准。主要观察指标:比较骨缺损愈合情况,以残腔封闭及新生骨密度为标准。结果:两组患者平均随访20个月。随访6个月时,实验组失访1例。随访18个月时实验组和对照组各失访2例。术后8个月两组患者的骨折愈合情况:骨缺损残腔消失,新骨组织与母骨融合为一体,密度和正常骨相同或高于正常骨,实验组44例,对照组46例;骨残腔基本消失,新生骨密度接近于正常骨,实验组12例,对照组10例。与自体骨移植材料相比,脱蛋白牛松质骨与自体红骨髓结合后对修复腔洞性骨缺损疗效相当。结论:应用脱蛋白牛松质骨结合自体红骨髓移植与自体骨移植修复腔洞性骨缺损,均可使腔洞性骨缺损残腔基本消失,新生骨密度接近正常骨,两种方法疗效相当。

Transplantation of deproteined bovine cancellous bone combined with autogenous red marrow for repairing bony cavity defect due to benign bone tumor: Compared with autologous bone graft

BACKGROUND: Autologous bone graft was always applied to repair bony cavity defect produced by benign bone tumor.OBJECTIVE: Taking autogenous bone graft for repairing bony cavity defect caused by bone tumor or tumor-like pathological change as control standard, to observe transplantation of deproteined bovine cancellous bone combined with autogenous red marrow in occluding the residual cavity and the density of newly formed bone.DESIGN: A randomized grouping design, controlled observation SETTING: Department of Orthopaedics, the 175 Hospital of Chinese PLA PARTICIPANTS:We recruited 175 cases of bony cavity defect who received treatment in the Department of Orthopaedics, the 175 Hospital of Chinese PLA from July 1993 to July 1998. They were randomly assigned into two groups: experimental group and control group. There were 63 cases treated in the experimental group. The average disease-suffering time was (6.2±2.1) months and bone defect was (136±30) mm3. There were 62 cases treated in the control group. The average disease-suffering time was (6.1±2.3)months, and bone defect was (133±37) mm3.METHODS: Deproteined bovine cancellous bone combined with autogenous red marrow was transplanted in the experimental group and autologous bone graft was applied in the control group. We curetted tumor completely, cauterized the wound with alcohol of 0.95 volume fraction, then curetted the area of cauterization to make it bled. Bone graft was applied.The quantity of implanted bone should be abundant, and disposed compactly. The X-ray films of the first week after operation were used as a standard for density of new bone growth. X-ray films were taken at the 3rd,6th and 8th months postoperatively, and the X-ray films of the eighth months after operation were used as a standard.MAIN OUTCOME MEASURES: To compare the bone union in two groups with a standard of residual cavity occluding and density of bone growth.RESULTS: All patients were followed up for an average of 20 months.One case was lost six months after operation. And two cases were lost eighteen months after operation respectively in the experimental group and control group. After 8 months of operation, residual cavities of bone defect of 44 cases in experimental group and 46 cases in control group were disappeared. Palingenetic bone fused with left bone organization. Its density was the same as or higher than normal bone organization. Residual cavities of 12 cases in experimental group and 10 cases in control group were disappeared basically. The density of palingenetic bone was approximate to normal bone organization. To compare with autologous bone graft, deproteined bovine cancellous bone and an autogenous red marrow had an identical effect for repairing bony cavity defect.CONCLUSION: Bony cavity defect produced by benign bone tumor is often repaired by bone transplantation. To explore the substitutable grafting materials of autogenous bone in this study, a composite material composed of deproteined bovine cancellous bone and an autogenous red marrow (DBCAM) is applied to repair the bony cavity defect.