食管癌外科治疗的预后因素分析

目的 探讨食管癌根治术后影响临床预后的因素.方法 回顾性分析我院1987年至2003年614例食管癌根治术后患者资料,采用Kaplan-Meier法计算生存率,Log-Rank检验比较生存差别和Cox多因素回归对本组病例的预后因素进行分析.结果 总的3年和5年生存率分别为34.1%,25.2%;年龄、病变长度、病理分期和术后辅助放疗是食管癌生存率影响因素(P均＜0.05);性别、肿瘤分化程度对食管癌生存率影响差异无统计学意义(P＞0.05).结论 高龄患者应充分考虑生理年龄,慎重选择手术治疗;早期诊断、早期手术治疗和术后规范辅助放疗,可提高食管癌患者生存率.

Analysis on factors influencing the prognosis of the patients subject to esophagectomy

Objective To investigate the factors influencing the prognosis of the patients subject to esophagectomy.Methods The clinical data of 614 patients with esophagus cancer from 1987 to 2003 were reviewed restrospectively.The survial rate was calculated with Kaplan-meier method.Comparisons of the difference in survival rate between groups were made according to the Log-Rank test.The prognosis factors were analyzed by Cox proportional harzard model.Results Generally,3-and 5-year survival rate was 34.1% and 25.2% respectively.Age,tumor length,TNM stage and postoperative radiotherapy were factors influencing the prognosis of the patients with esophagus cancer subject to esophagectomy (P>0.05); Sex and tumor differention had little infuence on the patient's prognosis (P>0.05).Conclusion Aged patients were selected prudently for surgery.Early diagnosis,early operation and postoperative radiotherapy can improve the long-term survival rate.