| 牛黄降压丸对正常大鼠血小板功能的影响与作用机制的实验研究 |
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| 引用本文： | 任建勋,林成仁,王敏,徐辉,刘建勋.牛黄降压丸对正常大鼠血小板功能的影响与作用机制的实验研究[J].中国实验方剂学杂志,2007,13(11):34-36. |
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| 作者姓名： | 任建勋 林成仁 王敏 徐辉 刘建勋 |
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| 作者单位： | 中国中医科学院西苑医院基础研究室,北京,100091 |
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| 摘 要： | 目的:观察牛黄降压丸对正常大鼠血小板功能影响并探讨其作用机制。方法:健康SD大鼠分别给予牛黄降压丸不同剂量(0.3,0.15,0.075 g.kg-1)灌胃7 d,观察正常大鼠的血小板黏附率,二磷酸腺苷二钠(ADP)诱导的血小板聚集率;采用放免法检测血小板中钙调蛋白(CaM)含量以及ADP诱导的血小板聚集时血栓素A2(TXA2)的释放。结果:牛黄降压丸可以抑制正常大鼠血小板黏附及ADP诱导的血小板聚集,降低血小板中CaM含量与TXA2的释放。结论:牛黄降压丸通过对引起血小板活化功能的不同途径的干预,抑制血小板的黏附及聚集。
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| 关 键 词： | 牛黄降压丸 血小板 作用机制 |
| 文章编号： | 1005-9903（2007）11-0034-03 |
| 收稿时间： | 2007-04-02 |
| 修稿时间： | 2007年4月2日 |
The Effect and Mechanism of Niuhuang Jiangya Capsule on the Function of Platelets in Rats |
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| REN Jian-xun,LIN Cheng-ren,WANG Min,XU Hui,LIU Jian-xun.The Effect and Mechanism of Niuhuang Jiangya Capsule on the Function of Platelets in Rats[J].China Journal of Experimental Traditional Medical Formulae,2007,13(11):34-36. |
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| Authors: | REN Jian-xun LIN Cheng-ren WANG Min XU Hui LIU Jian-xun |
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| Institution: | Xi Yuan Hospital,China Academy of Chinese Medicinal Sciences,Beijing 100091,China |
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| Abstract: | Objective:To study the effect and mechanism of Niuhuang Jiangya Capsule on the function of platelet in rats.Methods:Healthy SD rats were fed with Niuhuang Jiangya Capsule(0.3,0.15,0.075 g·kg-1)for 7days;then the platelet adhension rates and the ADP-induced platelet agglutinate rate as well as the contents of CaM and TXA2 in platelets were measured.Results:Niuhuang Jiangya Capsule could reduce the platelet adhension rate and the ADP-induced platelete agglutinate rate,as well as the contents of CaM and TXA2 in platelets.Conculsion:Niuhuang Jiangya Capsule can suppress platelet agglutinate and adhension by interventing different pathways of platelet activation. |
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| Keywords: | Niuhuang Jiangya Capsule platelet mechanism |
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