产超广谱β-内酰胺酶细菌致医院感染的分析

目的 :了解我院产超广谱β-内酰胺酶 (ESBLs)细菌致医院感染的发生率、分布情况及耐药特点。方法 :ESBLs菌的检测采用双纸片协同试验和纸片确认试验 ,细菌鉴定及药敏试验分别用法国生物梅里埃API鉴定系统和K -B法进行。结果 :在 4 80株革兰氏阴性杆菌中 ,产ESBLs菌占 2 8 13% (135 / 4 80 ) ,其中大肠埃希菌和肺炎克雷伯菌的阳性率分别为 2 4 89%和 35 34% ,产ESBLs菌对抗生素的耐药率均显著高于非产ESBLs菌 (P <0 .0 1) ,本文尚未发现对亚胺培南耐药菌株。结论 :临床实验室细菌鉴定应常规进行ESBLs检测 ,将有助于控制产ESBLs细菌的传播和流行 ,亚胺培南是治疗产ESBLs菌感染的首选药物

Analysis on the Hospital Infections Due to Extended Spectrum Batalaclose-Producing Bacteria

Objective;To investigate the incidence rate and distributed condition of the hospital infections due to extended spectrum batalaclose(ESBLs)-producing bacteria and the antibiotic resistance characterisation of the bacteria in our hospital.Methods:The ESBLs-producing bacteria assays were perfoumed with double-disk synergy test and compunud piece type confirm test.The bactrea identification and drug sesitivity tests were performed weith france bioMerieux-API identification system and K-B method,respectively.Result:Among 480 strains gram-negative bacilli,135 strains were ESBLs-producig bacteria(28.13%).Escherichia coli and klebasiella pneumoniae accounted for 24.89% and 35.34% of the ESBLs-producing bacteria,respectively,The antibiotic resistance rate of ESBLs producign bacteria was significantly higher than the non-ESBLs-producing bacteria(P<0.01).The resistance strains to imipenem were not detected.Conclusion:The ESBLs assay should routinely be done in the clinical laboratory bacteria identification,it s helpful to control the spread and epidemic of ESBLs-producing bacteria.Imipenen is first selected drug for treat ESBLs-producing bacteria infections.