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Cryopreserved aortic allografts for aortic root reconstruction: a single institution’s experience |
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| Authors: | Karl M Dossche MD Aart Brutel de la Rivire MD PhD Wim J Morshuis MD PhD Marc A A M Schepens MD PhD Joseph J A M Defauw MD Sjef M Ernst MD PhD |
| Institution: | a Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands b Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands |
| Abstract: | Background. An evaluation of early and long-term results of aortic root replacement with cryopreserved aortic allografts and echocardiographic follow-up of allograft valve function was performed. Methods. From September 1989 through May 1998, 132 patients aged 17 to 77 years (mean, 50.8 ± 14.8 years) underwent freestanding aortic root replacement with a cryopreserved aortic allograft. Eighty-six (65.1%) patients had New York Heart Association class III or IV functional status before operation, and 27 (20.5%) patients underwent emergency operation. Fifty-nine (44.7%) patients had undergone previous cardiac operations. The cause of aortic disease was acute endocarditis in 63 (47.7%) patients, healed endocarditis in 15 (11.3%), degenerative in 20 (15.2%), congenital in 20 (15.2%), failed prosthesis in 10 (7.6%) and rheumatic in 4 (3.0%). Follow-up was complete, with a mean of 42 months. Results. There were 12 hospital deaths (9.1%; 70% confidence limits CL], 6.6% and 11.6%); 9 of them were operated on for active endocarditis (p = 0.062). Multivariate analysis determined age older than 65 years (p = 0.012) and emergency operation (p = 0.009) as independent risk factors for hospital mortality. During follow-up, 6 (5.0%; 70% CL, 3.0% and 7.0%) patients died. Cumulative survival rate for the entire group was 81.8% ± 5.4% at 8 years. Freedom from reoperation for structural valve failure was 100%, freedom from reoperation for any cause was 96.3% ± 1.8% at 8 years. Freedom from endocarditis at 8 years was 97.9% ± 1.4%. Follow-up of allograft valve function showed no or trivial aortic regurgitation in 97% of patients and absence of stenosis of the allograft in 100%. Conclusions. Aortic root replacement with cryopreserved aortic allografts can be performed with acceptable hospital mortality and long-term results. The durability of cryopreserved aortic allografts is good, and reoperation for structural valve failure is absent at 8 years. |
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