藏族人群乙型肝炎疫苗免疫应答

目的考核酵母基因工程乙肝疫苗在易感藏族人群中的免疫原性。方法为1 609名从横断面调查中筛选出的HBV易感者接种汉逊酵母乙型肝炎疫苗,剂量10ug/mL,程序0、1、6个月。免疫7个月后,随机整群选择615名接种者采集静脉血标本,固相放射免疫(RIA)法定性检测HBsAg、抗-HB,Abbott公司的MEIA试剂定量检测抗-HBs。结果共549名接种者抗-HBs阳转,阳转率89.3%,抗-HBs阳转者几何平均浓度(GMC)为3 514.6mIU/mL;抗体阳转率和GMC均呈随年龄降低的趋势,而与接种者的性别、职业、居住地等无关;观察结束时检出8名HBsAg阳转者,其原因待查。结论藏族人群对基因工程乙肝疫苗有良好的免疫应答。

The immune response of hepatitis B vaccine in Tibetan nationality

Objective To observe the immunogenicity of YDV(Yeast-derived hepatitis B vaccine) among susceptible Tibetan population.Method 1 609 HBV susceptibles were selected by cross-sectional survey,which were inoculated with YDV of 10μg/ml at the 0,1st and 6th month.After 7 months of immune,randomly selected 615 venous blood samples.HBsAg and anti-HB were qualitative detection by RIA,and anti-HBs was quantitative detection by MEIA reagent which produced by Abbott company.Results It was shown that 549 inoculators’ anti-HBs were seroconversion,the seroconversion rate was 89.3%,and the geometric mean concentration(GMC) of anti-HBs seroconversion was 3 514.6mIU/mL.Both antibody seroconversion rate and GMC were decreased with the age increased,and they had no relation with gender,occupations,habitations of inoculators.At the end of observation,there were 8 cases of HBsAg positive,which need further investigation.Conclusions Tibetan nationality crowds have a good immune response to Yeast-derived hepatitis B vaccine.