西肽普兰合并曲唑酮治疗老年抑郁症疗效观察

目的:探讨西肽普兰合并曲唑酮治疗老年抑郁症的临床疗效。方法:将74例老年抑郁症患者随机分为治疗组(西肽普兰服用剂量为20～40 mg.d-1合并曲唑酮服用剂量50～150 mg.d-1)及对照组(单用西肽普兰)各37例,疗程6周。分别于治疗后1、2、6周末用汉密尔顿抑郁量表,汉密尔顿焦虑量表评定疗效,以症状量表(TESS)评定治疗中出现的不良反应。结果:2组治疗后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)总分比较差异有统计学意义(P<0.05),治疗组的不良反应比对照组重,主要表现有头昏、嗜睡,但患者均能耐受。结论:西肽普兰合并曲唑酮治疗抑郁症比对照组临床疗效更好。

Observation on the therapeutic effect of citalopram combined with trazodone in the treatment of geriatric depression

OBJECTIVE To observation the efficacy of citalopram in combination with trazodone in the treatment of geriatric depression.METHODS A total of 74 depression patients were randomized into two groups.The patients in research group were treated with citelopram combined with trazodone,those in control group with citelopram.The course of treatment was 6 weeks for both groups.HAMDS HAMA and TESS were used to evaluate the efficacy and side effects at the end of week 1,2,6.RESULTS The differences between research group and control group before and alter treatment were significant in terms of HAMA and HAMD scores(P<0.05).Side effects of patients in research group was expressed as dizziness and drowsiness,but tolerable.CONCLUSION The effects of citalopram combined with trazodone in the treatment of geriatric depression were better than those in control group.