剖宫产围手术期抗生素使用与新生儿高胆红素血症相关性研究

目的探讨产妇抗生素使用对新生儿高胆红素血症的影响。方法将220例剖宫产产妇行抗生素治疗,均分为2组:研究组于手术前给头孢唑啉1.0 g配入0.9%氯化钠注射液100 mL,静脉滴注。术后同等剂量,间隔8 h1次,共3次。对照组术前未用药,术后给头孢唑啉2.0 g配入0.9%氯化钠注射液250 mL,静脉滴注,2次/d,共3 d。观察两组新生儿高胆红素血症发生率,同时观察两组产褥感染发生率。结果两组不同时间的抗生素使用对新生儿高胆红素发生率具有显著性差异(P<0.05);两组产褥感染发生率无显著性差异(P>0.05)。结论产妇围术期用药可减低新生儿高胆红素血症的发生,缩短用药时间。

The Relationship between Usage of Antibiotics and Neonatal Hyperbilirubinemia Perioperative Cesarean Section

Objective To investigate the effect on maternal neonatal hyperbilirubinemia by use of antibiotics in puerperant.Methods Two hundred twenty cases of cesarea section to antibiotic treatment were divided into 2 groups.The patients in research group were intravenously dripped with cefazolin 1.0 g dissolved in 0.9% sodium chloride injection 100 mL preoperative.The same dose drug was taken interval 8h,three times a day postoperative.The patients were intravenously dripped with cefazolin 2.0 g dissolved in 0.9% sodium chloride injection 250 mL twice a day for 3 d postoperative in control group which did not administrate drug.The neonatal hyperbilirubinemia and puerperal infection incidences were observed in two groups.Results The incidences of neonatal hyperbilirubinemia were significantly different in different times of the use of antibiotics in two group(P<0.05).Conclusion Perioperative medication could reduce occurrence of neonatal hyperbilirubinemia and short medication time.