| 清络通痹颗粒对佐剂性关节炎大鼠滑膜细胞的影响 |
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| 引用本文： | 周玲玲,方泰惠,周学平,王明艳,梁卫,梁涛.清络通痹颗粒对佐剂性关节炎大鼠滑膜细胞的影响[J].中国中医药信息杂志,2004,11(8):680-681. |
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| 作者姓名： | 周玲玲 方泰惠 周学平 王明艳 梁卫 梁涛 |
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| 作者单位： | 南京中医药大学,江苏,南京,210029 |
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| 摘 要： | 目的探讨清络通痹颗粒对佐剂性关节炎大鼠滑膜细胞的影响.方法建立佐剂性关节炎(AIA)大鼠模型,同时设正常对照组.自第7天开始给药,持续21 d.取滑膜,检测滑膜细胞增殖能力和滑膜细胞分泌IL-1的量.结果清络通痹颗粒7.2、14.4 g/kg可明显抑制AIA大鼠的滑膜细胞增殖反应(P＜0.01).结论一定剂量的清络通痹颗粒可抑制AIA大鼠滑膜细胞的过度增生,这与其调节与滑膜增生相关的细胞因子有关.
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| 关 键 词： | 清络通痹颗粒 佐剂性关节炎 白介素-1 滑膜细胞 |
| 文章编号： | 1005-5304(2004)08-0680-02 |
| 修稿时间： | 2003年10月25 |
Effects of Qingluotongbi Granule on the Synoviocytes of Adjuvant Induced Arthritis Rats |
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| ZHOU Ling-ling,FANG Tai-hui,ZHOU Xue-ping,et al.Effects of Qingluotongbi Granule on the Synoviocytes of Adjuvant Induced Arthritis Rats[J].Chinese Journal of Information on Traditional Chinese Medicine,2004,11(8):680-681. |
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| Authors: | ZHOU Ling-ling FANG Tai-hui ZHOU Xue-ping |
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| Abstract: | Objective To observe the effects and mechanism of Qingluotongbi Granule (QLT) on the synoviocytes of adjuvant induced arthritis (AIA) model of rats. Methods The AIA model was induced with Freund complete adjuvant. Drugs were given on the seventh day. On the 28th day, the proliferation of synoviocytes and the level of IL-1 in synoviocytes were detected. Results QLT 7.2,14.4 g/kg markedly decreased the proliferation of synoviocytes and the level of IL-1 in synoviocytes of AIA rats. Conclusion QLT can inhibit the proliferation of synovial membrane of AIA rats. That can be related to the modulation of cytokines. |
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| Keywords: | Qingluotongbi Granule adjuvant induced arthritis interleukin-1 synoviocyte |
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