Conformational modification of the PRP-hexapeptide by a direct covalent attachment of aromatic side chain groups |
| |
| Authors: | ZBIGNIEW SZEWCZUK,ALEKSANDRA KUBIK,IGNACY Z. SIEMION,ZBIGNIEW WIECZOREK,KRYSTYNA SPIEGEL,MICHAL ZIMECKI,MARIA JANUSZ,J
ZEF LISOWSKI&#x |
| |
| Affiliation: | ZBIGNIEW SZEWCZUK,ALEKSANDRA KUBIK,IGNACY Z. SIEMION,ZBIGNIEW WIECZOREK,KRYSTYNA SPIEGEL,MICHAL ZIMECKI,MARIA JANUSZ,JÓZEF LISOWSKI† |
| |
| Abstract: | PRP-hexapeptide possessing the azo-bridge between Tyr1 and Phe5 residues, called  azo-PRP-hexapeptide: Tyr-Val-Pro-Leu-Phe-Pro, was synthesized and tested for immunoregulatory activity. High biological activity of the synthesized azo-PRP-hexapeptide suggests that the biologically active conformation of PRP-hexapeptide must be such that both aromatic rings (Tyr and Phe) are apparently close to each other. |
| |
| Keywords: | azo-PRP-hexapeptide azo-bridged peptide peptide immunoeffectors |
|
|
