骨瓜提取物注射液对骨质疏松性椎体压缩骨折患者疼痛缓解及骨密度的影响

目的探析骨质疏松性椎体压缩骨折患者应用骨瓜提取物注射液对疼痛及骨密度的影响。方法对2017年1月~2018年12月在某院进行治疗的84例骨质疏松性椎体压缩骨折患者进行分组研究,采用抽签法分为对照组(n=42)与研究组(n=42)。对照组应用锝99Tc]亚甲基二膦酸盐注射液治疗,在此基础上,研究组联合应用骨瓜提取物注射液治疗,对比两组临床疗效及疼痛程度、骨密度、骨钙素水平变化。结果研究组临床总有效率为95.24%,对照组为78.57%,差异有统计学意义(P<0.05)。研究组治疗2个月、6个月后疼痛评分均低于对照组,差异有统计学意义(P<0.05)。研究组治疗6个月后骨密度大于对照组,差异有统计学意义(P<0.05)。研究组治疗6个月后骨钙素水平低于对照组,差异有统计学意义(P<0.05)。结论骨质疏松性椎体压缩骨折患者应用骨瓜提取物注射液治疗,可进一步提高临床效果,缓解疼痛,增加骨密度。

Effect of Gugua extract injection on pain relief and bone mineral density in patients with osteoporotic vertebral compression fracture

Objective To study the effect of Gugua extract injection on pain relief and bone mineral density in patients with osteoporotic vertebral compression fracture.Methods A total of 84 patients with osteoporotic vertebral compression fractures who were treated in our hospital from January 2017 to December 2018 were divided into control group(n=42)and study group(n=42).The patients in the control group were treated with99Tc]methylenebisphosphonate injection.On the basis of this,the study group was treated with Gugua extract injection.The clinical efficacy and pain degree,bone mineral density and osteocalcin were compared between the two groups.Results The total effective rate of the study group was 95.24%,and that of the control group was 78.57%.The difference was statistically significant(P<0.05).The pain scores of the study group were lower than the control group after 2 months and 6 months,and the difference was statistically significant(P<0.05).The bone mineral density of the study group was greater than that of the control group after 6 months of treatment,and the difference was statistically significant(P<0.05).The osteocalcin level of the study group was lower than that of the control group after 6 months of treatment,and the difference was statistically significant(P<0.05).Conclusion Patients with osteoporotic vertebral compression fractures treated with Gugua extract can further improve clinical outcomes,relieve pain and increase bone density.