谷氨酸受体在左旋多巴诱导的异动症中的相关研究进展

在帕金森病(PD)患者中,长期使用左旋多巴而诱导的异动症(LID)显著影响着左旋多巴的疗效及患者的生活质量,现有的应对方案效果也均不甚理想,其原因与LID的机制目前尚未完全阐明密切相关。近年来越来越多的研究证实,谷氨酸能系统与多巴胺能系统紧密关联,谷氨酸受体在LID中的作用也日益凸显,特别是代谢型谷氨酸受体(mGluR)4、mGluR5以及部分离子型谷氨酸受体(iGluRs)在LID的机制研究和临床药物研究中更是关注热点。笔者现对各类谷氨酸受体在LID中的变化、作用以及相关的临床研究进展进行综述,以期为PD患者中LID的诊治和机制阐明提供新思路。

Recent advance in glutamate receptor in levodopa-induced dyskinesia

In Parkinson's disease(PD),long-term use of levodopa-induced dyskinesia(LID)significantly affects the therapeutic efficacy of levodopa and quality of life of patients.Current existing therapies are not ideal,which is related to that mechanism of LID has not been fully clarified.Recently,more and more studies have confirmed that the glutamatergic system is closely related to the dopaminergic system,and the role of glutamate receptors in LID is increasingly prominent,especially,metabolic glutamate receptor(mGluR)4,mGluR 5 and partial ionotropic glutamate receptors are current research hotspots in the mechanism and clinical observation of drugs of LID.Therefore,this review summarizes the changes and roles of various glutamate receptors in LID and related clinical studies,hoping to provide new ideas for the diagnosis and treatment of LID in PD patients.