Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion

Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser, and the total period of tachycardia and fibrillation were 3-fold shorter than in the control. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 25–27, January, 1995 Presented by S. S. Debov, Member of the Russian Academy of Medical Sciences