| 诱导分化治疗中端粒酶活性的改变及其意义 |
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| 引用本文： | 傅 王玮 岑建农 陈子兴. 诱导分化治疗中端粒酶活性的改变及其意义[J]. 苏州大学学报(自然科学版), 2001, 21(4): 387-389 |
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| 作者姓名： | 傅 王玮 岑建农 陈子兴 |
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| 作者单位： | 傅（苏州大学附属第一医院血液科，江苏省血液研究所，苏州 215006） 王玮（苏州大学附属第一医院血液科，江苏省血液研究所，苏州 215006） 岑建农（苏州大学附属第一医院血液科，江苏省血液研究所，苏州 215006） 陈子兴（苏州大学附属第一医院血液科，江苏省血液研究所，苏州 215006） |
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| 基金项目： | 98江苏省 333工程科研项目基金资助，苏州医学院科研基金 (E970 5 )资助 |
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| 摘 要： | 目的研究诱导分化治疗中端粒酶活性的变化规律。方法对白血病细胞株、正常骨髓和急性白血病的骨髓单个核细胞的端粒酶活性进行了检测，观察了全反式维甲酸(ATRA)在体外和体内分化诱导过程中端粒酶活性的改变。结果发现端粒酶表达下调是诱导分化的早期效应之一。诱导分化治疗可使急性白血病M3早幼粒细胞端粒酶活性水平降至正常。结论在体内和体外实验中，ATRA诱导分化过程中伴随着端粒酶活性下调。
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| 关 键 词： | 端粒酶；全反式维甲酸；急性白血病；分化 |
| 文章编号： | 1000-5749(2001)04-0387-03 |
| 修稿时间： | 2000-11-10 |
Alteration of Telomerase Activity during Differentiation Induction Therapy and Its Clinical Significance |
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| FU Zheng-zheng,WANG Wei,CENG Jian-nong,et al. Alteration of Telomerase Activity during Differentiation Induction Therapy and Its Clinical Significance[J]. Suzhou University Journal of Medical Science, 2001, 21(4): 387-389 |
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| Authors: | FU Zheng-zheng WANG Wei CENG Jian-nong et al |
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| Abstract: | Objective To study the regulation of telomerase activity during differentiation therapy.Methods The telomerase activity was detected in the bone marrow mononuclear cells of acute leukemia,normal individuals and leukemia cell lines. The alteration of telomerase activity was observed during in vivo or in vitro differentiation induction procedure by all trans retinoic acid.Results Down regulation of telomrase expression was discovered as an early effect of differentiation induction.Telomerase activety of promyelocytic cells in acute leukemia M3 was inhibited to an undetectable level during differentiation therapy.Conclusions Telomerase activity was down regulated during the course of differentiation induction by all trans retinoic acid in vivo or in vitro experiment. |
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| Keywords: | Telomerase all trans retinoic acid acute leukemia differentiation |
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