Ifosfamide/mesna as salvage therapy in platinum pretreated ovarian cancer patients--long-term results of a phase II study |
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Authors: | Baur Martina Fazeny-Doerner B Hudec M Sevelda P Salzer H Dittrich Christian |
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Affiliation: | a Ludwig Boltzmann-Institute for Applied Cancer Research, Vienna, Austriab Applied Cancer Research-Institution for Translational Research Vienna, Vienna, Austriac 3rd Medical Department with Oncology, Kaiser Franz Josef-Spital, Vienna, Austriad Division of Oncology, Department of Internal Medicine I, University of Vienna, Vienna, Austriae Department for Statistics, University of Vienna, Vienna, Austriaf Department of Gynecology and Obstetrics, Krankenhaus Lainz, Vienna, Austriag Department of Gynecology and Obstetrics, Wilhelminenspital, Vienna, Austria |
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Abstract: | Purpose: Salvage chemotherapy in advanced ovarian cancer is not yet standardized. Patients: Twenty-one consecutive patients progressing on or relapsing after previous platinum-containing treatment were eligible for treatment with ifosfamide 5 g/m2 infused over a 24-hour period every 3 weeks in a Phase II trial. After an initial bolus of 1 g/m2 of mesna, mesna was applied at a dosage of 5 g/m2 concomitantly with ifosfamide followed by additional dosages of 200 mg 3 times at 4-hour intervals after termination of the ifosfamide infusion. Results: The rate of objective responses was 19 percent, with a 95%CI [5.45-41.91 percent]. One patient achieved a pathologic complete remission (pCR) and 3 patients a clinical partial remission (PR). Median time-to-progression was 3 months. One patient was a long-term survivor. Main toxicities according to NCI-CTC included Grade 4 neurotoxicity in one patient, Grade 3 gastrointestinal toxicity in 5 patients, Grade 3 infection in one patient, and Grade 3 and 4 leucopenia in 6 and 2 patients, respectively. Conclusions: Monotherapy with ifosfamide represents an active regimen for salvage chemotherapy in advanced ovarian cancer patients progressing on or relapsing after previous platinum-pretreatment, even yielding a long-term surivor. |
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Keywords: | Ifosfamide Mesna Advanced ovarian cancer Platinum pretreatment Salvage therapy |
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