^125I放射性粒子术中植入治疗晚期胰腺癌的疗效评价

目的初步分析^125I放射性粒子术中植入内照射治疗晚期胰腺癌的临床疗效。方法对22例手术不能切除的晚期胰腺癌在术中植入^125I放射性粒子进行组织间内照射。结果全组22例，生存期〉20个月5例，〉10—20个月9例，2—10个月8例，平均生存期（13．47±8．12）个月。CR5例，PR8例，NC7例，PD2例。总有效率（CR＋PR）为59％。治疗后9例3级疼痛患者中5例转为1级；13例4级疼痛患者中7例转为2级，2例转为1级。止痛有效率为59％。结论^125I放射性粒子术中植人内照射治疗晚期胰腺癌有一定疗效。

Evaluation of therapeutic effects with inlra ( Need to be modified by authors ) -operative iodine-125 seed implantation for advanced pancreatic carcinoma

Objective To analyze the clinical effects of internal radiation of iodine-125 seed implantation in the treatment of advanced pancreatic carcinoma. Methods 22 patients with unreseetable and advanced pancreatic carcinoma were treated by the internal and interstitial radiation using iodine-125 seed implantation. Results Survival of 20 months was observed in 5 patients, 10 - 20 months in 9 patients, 2 - 10 months in 8 ,patients with an average of （13.47 ＋ 8.12 ）months. Among the 22 patients, complete response was obtained in 5 patients, partial response in 8 patients, no response in 7 patients, and the other showing PD. The response rate（ CR ＋ PR） was 59%. Conclusions Intra - operative internal radiation by iodine - 125 seed implantation does show some therapeutic effects for advanced pancreatic carcinoma.