Susceptibility of Enterobacteriaceae to β-lactam agents and fluoroquinolones: a 3-year survey in France |
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Authors: | J Sirot M H Nicolas-Chanoine H Chardon J L Avril C Cattoen J C Croix H Dabernat T Fosse J C Ghnassia E Lecaillon A Marmonier M Roussel-Delvallez C J Soussy A Trevoux F Vandenesch C Dib N Moniot-Ville Y Rezvani |
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Institution: | Centre Hospitalo-Universitaire, Clermont-Ferrand,;Centre Hospitalo-Universitaire Ambroise Paré, Boulogne-Billancourt,;Centre Hospitalier d'Aix-en-Provence,;Centre Hospitalo-Universitaire Pontchaillou, Rennes,;Centre Hospitalier de Valenciennes,;Centre Hospitalier de Troyes,;Centre Hospitalo-Universitaire Purpan, Toulouse,;Center Hospitalo-Universitaire de l'Archet II, Nice,;Centre Hospitalier A. Mignot, Versailles,;Centre Hospitalier de Perpignan,;Centre Hospitalier du Mans,;Center Hospitalo-Universitaire A. Calmette, Lille,;Centre Hospitalo-Universitaire Henri Mondor, Créteil,;Centre Hospitalier Emile Muller, Mulhouse,;Centre Hospitalo-Universitaire Louis Pradel, Bron and;Laboratoire Aventis, Paris, France |
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Abstract: | Objective To assess trends in the susceptibility to β -lactam agents and to fluoroquinolones of clinically relevant Enterobacteriaceae isolated over a 3-year period in 14 French hospital laboratories. Methods During the second quarter of 1996, 1997 and 1998, 180 consecutive non-duplicate isolates of Enterobacteriaceae were collected in each center. Sixteen β -lactams and four quinolones were tested by the disk diffusion method. In addition, the double-disk synergy test was used to screen for the production of extended-spectrum β -lactamase (ESBL). Results Totals of 2507, 2312 and 2506 clinical isolates were obtained in each period, respectively. The distribution of Enterobacteriaceae species according to clinical specimens and wards was similar in each study period. No significant variation in the susceptibility rates to β -lactams and fluoroquinolones was observed, except in Klebsiella pneumoniae and Enterobacter aerogenes. The prevalence of ESBL-producing isolates decreased from 18% to 9% in the former, while it increased from 32% to 54% in the latter. At the same time, the susceptibility to ofloxacin and pefloxacin increased for K. pneumoniae ( P < 0.003) and cephalosporinase-producing species ( P < 0.05), except Enterobacter spp. Conclusion Over the 3-year study period β -lactams and fluoroquinolones remained highly active against Enterobacteriaceae clinical isolates, with the exception of E. aerogenes , probably as a result of the dissemination of multiresistant clones in French hospitals. |
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Keywords: | Enterobacteriaceae resistance β-lactams fluoroquinolones |
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