hsCRP、BNP、D-二聚体联合检测对急性心血管病的诊断价值

目的探讨联合检测高敏C反应蛋白(hsCRP)、B型钠尿肽(BNP)、D-二聚体对急性心血管疾病临床诊治价值。方法选取2019年1月~2020年1月于本院急诊监护室住院的急性心血管疾病患者80例,将此80例患者作为观察组,另将80例在本院同期健康体检的正常人纳为对照组。将两组hsCRP、BNP、D-二聚体水平进行比较,并将观察组治疗前后的hsCRP、BNP、D-二聚体水平比较;观察组在治疗后发生与未发生不良心血管事件(MACE)患者hsCRP、BNP、D-二聚体水平比较。结果两组hsCRP、BNP、D-二聚体水平比较,观察组均显著高于对照组(P<0.05);治疗后,观察组患者在hsCRP、BNP、D-二聚体水平上显著低于治疗前(P<0.05),观察组患者在治疗后,发生MACE的患者hsCRP、BNP、D-二聚体水平显著高于未发生MACE患者(P<0.05);在特异度、灵敏度、阴性预测值、阳性预测值与联合检测间比较,hsCRP、BNP、D-二聚体的联合检测均显著高于单独检测(P<0.05);在特异度上,hsCRP、BNP、BNP、D-二聚体的联合检测均显著高于单独检测(P<0.05)。结论 hsCRP、BNP、D-二聚体联合检测对急性心血管疾病的临床诊断价值较单独检测更高,值得临床推广应用。

Diagnostic value of combined detection of hsCRP,BNP,D-dimer in acute cardiovascular disease

Objective To explore the combined detection of hsCRP,BNP,D-dimer in acute cardiovascular disease and analyze its clinical diagnostic value.Methods 80 patients with acute cardiovascular diseases hospitalized in our hospital from January 2019 to January 2020 were selected as observation group and 80 normal subjects who underwent physical examination at the same time as control group.The level of hsCRP,BNP,D-dimer in the two groups was compared;the level of hsCRP,BNP,D-dimer in the observation group was compared before and after treatment;the occurrence and absence after treatment were compared with those in the observation group before and after treatment.Comparison of hsCRP,BNP,D-dimer levels in(MACE)patients with adverse cardiovascular events.Results Compared with the control group,the level of hsCRP,BNP,D-dimer in the observation group was significantly higher than that in the control group,the level of hsCRP,BNP,D-dimer in the observation group was significantly lower than that before treatment,and the level of hsCRP,BNP,D-dimer in the observation group was significantly higher than that in the patients without MACE after treatment.The combined detection of hsCRP,D-dimer was significantly higher than that of single detection in specificity,sensitivity,negative predictive value,positive predictive value and combined detection(P<0.05).In terms of specificity,the combined detection of hsCRP,BNP,Ddimer was significantly higher than that of single detection(P<0.05).Conclusions The clinical value of the combination of hsCRP,BNP and D dimer in the detection of acute cardiovascular disease is higher than that of the detection alone.