Classical Risk Factors for Ischemic Stroke are not Associated with Inpatient Post-Stroke Mortality in Sickle Cell Disease |
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| Affiliation: | 1. Albert Einstein College of Medicine, Bronx, NY 10461***, USA;2. Montefiore Medical Center, Bronx, NY 10467, USA;3. Leo M. Davidoff Department of Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3316 Rochambeau Ave., Bronx, NY 10467, USA;1. Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idai-dori, Yahaba, Iwate 028-3694, Japan;2. Department of Neurosurgery, Iwate Medical University, Yahaba, Iwate, Japan;2. Community Center, The Atahualpa Project, Atahualpa, Ecuador;3. Department of Epidemiology, Gilead Sciences, Inc., Foster City, CA, USA;1. Department of Neurology, Brigham and Women''s Hospital, Boston, MA;2. Department of Neurology, Massachusetts General Hospital, Boston, MA;3. Harvard Medical School, Boston, MA;1. Bachelor of Applied Science Physiotherapy (honours), Master Clinical Rehabilitation, Physiotherapist, Rehabilitation, Aged Care, and Palliative Division, Southern Adelaide Local Health Network: c/o Flinders Medical Centre, Flinders Drive, Bedford Park, South Australia, 5042, Australia;2. Bachelor Physiology, Sports Science and Nutrition (honours), Masters Research Bioengineering, PhD Bioengineering, College of Nursing and Health Sciences, Flinders University: GPO Box 2100, Adelaide 5001, South Australia, Australia;3. Bachelor of Applied Science (Exercise and Sports Science), Human Movement (honours), PhD Health Sciences, College of Nursing and Health Sciences, Flinders University; GPO Box 2100, Adelaide 5001, South Australia, Australia;4. Bachelor of Physiotherapy, Master of Movement Sciences, PhD Rehabilitation Sciences, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia;1. Center for Outcomes Research, Houston Methodist, Houston, TX, United States;2. University of Texas Southwestern at Dallas, United States;3. Houston Methodist Neurological Institute, Houston Methodist, Houston, TX, United States |
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| Abstract: | ObjectivesSickle cell disease is a common haemoglobinopathy that significantly increases the risk of ischemic stroke. Because the risk factors for ischemic stroke onset and mortality in non-sickle cell disease patients have been largely elucidated, this paper aims to analyze risk factors for ischemic stroke mortality in sickle cell disease patients, which remain largely unknown.Materials/MethodsThe National Inpatient Sample database (2016–2017) was used to develop a multivariable regression model for risk quantification of known ischemic stroke risk factors for in-hospital mortality in ischemic stroke patients with and without sickle cell disease.ResultsClassical risk factors for ischemic stroke onset, including ischemic heart disease, carotid artery disease, lipidemias, hypertension, obesity, tobacco use, atrial fibrillation, personal or family history of stroke, congenital heart defects, congestive heart failure, cardiac valve disorder, peripheral vascular disease, and diabetes mellitus are associated with in-hospital mortality in non-sickle cell patients (p < 0.05). However, no significant association was found between these stroke risk factors and in-hospital mortality in sickle cell disease patients presenting with ischemic stroke (p > 0.05).ConclusionsWhile the classical risk factors for stroke onset are associated with in-hospital mortality in non-sickle cell stroke patients, they are not associated with in-hospital mortality in sickle cell stroke patients. |
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