异甘草素抗肿瘤作用及其机制研究进展

异甘草素(ISL)是从甘草根茎中提取的生物活性成分之一。近年来,众多研究表明,ISL药理特性丰富,有抗癌、抗炎、抗氧化、抗过敏、抗心律失常、保肝、治疗艾滋病和免疫调节等作用,尤其抗肿瘤作用近年来成为研究的热点。本文就异甘草素常见抗肿瘤作用及可能的机制研究进展做出综述,为异甘草素进一步的研究和抗肿瘤新药的开发提供理论依据。

Progress of researches in anti-tumor effects and mechanisms of isoliquiritigenin

Isoliquiritigenin(ISL)is one of the biologically active components extracted from the stems of licorice.In recent years,many studies have shown that ISL has rich pharmacological properties,such as anti-cancer,anti-inflammation,anti-oxidation,anti-allergy,anti-arrhythmia,liver protection,being effective in the treatment of HIV/AIDS and immunomodulatory effect;in particular,the anti-tumor effect has gradually become a research hotspot.This paper reviews the research progress of common anti-tumor effects and possible mechanisms of isoliquiritigenin,and provides a theoretical basis for the further researches of isoliquiritigenin and the development of new anti-tumor drugs.