Integrity of the Inferior Cerebellar Peduncle Correlates with Ambulatory Function after Hemorrhagic Stroke |
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| Affiliation: | 1. Department of Rehabilitation Medicine, Yeouido St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;2. Department of Family Medicine, St. Vincent''s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea;3. Department of Rehabilitation Medicine, St. Vincent''s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea;4. Rehabilitation Medicine, Independent Scholar, Seoul, Republic of Korea;1. Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan;2. Division of Diabetes and Metabolic Diseases, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan;3. Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan;1. Department of Neurology, Seoul St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea;2. Department of Neurology, St. Vincent''s Hospital, College of Medicine, The Catholic University of Korea, 93, Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, Republic of Korea;1. Department of Anesthesiology, Division of Neurological Anesthesia, Thomas Jefferson University Hospital, Philadelphia, PA, USA, 19107;2. Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA, 19107;1. Bachelor of Applied Science Physiotherapy (honours), Master Clinical Rehabilitation, Physiotherapist, Rehabilitation, Aged Care, and Palliative Division, Southern Adelaide Local Health Network: c/o Flinders Medical Centre, Flinders Drive, Bedford Park, South Australia, 5042, Australia;2. Bachelor Physiology, Sports Science and Nutrition (honours), Masters Research Bioengineering, PhD Bioengineering, College of Nursing and Health Sciences, Flinders University: GPO Box 2100, Adelaide 5001, South Australia, Australia;3. Bachelor of Applied Science (Exercise and Sports Science), Human Movement (honours), PhD Health Sciences, College of Nursing and Health Sciences, Flinders University; GPO Box 2100, Adelaide 5001, South Australia, Australia;4. Bachelor of Physiotherapy, Master of Movement Sciences, PhD Rehabilitation Sciences, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia;1. Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (Department of Medicine), C/Sant Antoni Maria Claret 167, 08025, Barcelona, Spain.;2. Cerebrovascular Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), C/Sant Quintí 77, 08041, Barcelona Spain.;3. Facility of Cytometry, Biomedical Research Institute Sant Pau (IIB-Sant Pau), C/Sant Quintí 77, 08041, Barcelona, Spain |
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| Abstract: | ObjectivesCerebro-cerebellar connectivity plays a critical role in motor recovery after stroke; however, the underlying mechanism of walking recovery is unclear. The dorsal spinocerebellar pathway has been suggested as a biomarker of poststroke ambulatory function. We aimed to explore the association between ambulatory function and the dorsal spinocerebellar pathway's integrity after intracerebral hemorrhage (ICH).Materials and methodsTwenty-seven patients with ICH who were admitted for inpatient rehabilitation during the subacute phase of stroke and 27 age-matched healthy controls were included retrospectively. Ambulatory function was assessed using the Berg Balance Scale and Mobility score. We measured the fractional anisotropy (FA) values of the corticospinal tract (CST) and inferior cerebellar peduncle (ICP) as the final route of the dorsal spinocerebellar pathway. The FA laterality indices, representing the degree of degeneration, were calculated. A Spearman correlation analysis and multivariate linear regression models were used to determine the associations between the FA laterality indices and ambulatory function.ResultsAn FA reduction was found in both the ipsilesional CST and contralesional ICP of the patients. The ICP FA laterality index exhibited a moderate correlation with ambulatory function (Berg Balance Scale, ρBBS=0.589; Mobility score, ρMS=0.619). On dividing the patient group into the moderate (mRS 3, 4) and severe disability (mRS 5) groups, a stronger correlation was found (ρBBS=0.777, ρMS=0.856, moderate disability; ρBBS=0.732, ρMS=0.797, severe disability). The ICP FA laterality index and age were independently associated with the Mobility score (R2=0.525).ConclusionsICP degeneration occurs after ICH, and its degree is associated with ambulatory function after ICH. |
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