Associations of Circulating Levels of Sphingosine 1-Phosphate with the Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women |
| |
| Institution: | 1. Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea;2. Asan Institute for Life Sciences, Seoul 05505, Republic of Korea;3. SEJONG BIOMED CO., LTD., Paju 10880, Republic of Korea;4. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea;1. Medical Service, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA;2. Department of Veterans Affairs Rehabilitation Research & Development Service, National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA;3. Departments of Medicine and Rehabilitation and Human Performance, Icahn School of Medicine at Mount, Sinai, New York, NY, USA;4. Department of Physical Therapy, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ;5. Departments of Medical Sciences and Neurology, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USA;6. Kessler Institute for Rehabilitation, West Orange, NJ;7. Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ;8. School of Kinesiology, University of Minnesota, Minneapolis, MN;9. Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA;1. University of Manitoba, Winnipeg, Canada;2. University of Hawaii Cancer Centre, Honolulu, USA;1. University of Wisconsin, Osteoporosis Clinical Research Program, Madison, WI, USA;2. Research and Development Department, Medimaps, Bordeaux, France;3. Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;4. University of Wisconsin, Department of Orthopedics and Rehabilitation, Madison, WI, USA;1. Department of Emergency, Hospital Santa Ana, Granada, Spain;2. Department of Rheumatology, Hospital Vega-Baja, Alicante, Spain;3. Infectious Diseases Unit, Hospital General de Elche, Alicante, Spain;4. Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain;5. Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain;6. School of Medicine, University of Granada, Granada, Spain;7. Instituto de Investigación Biosanitaria, IBS, Granada, Spain;1. Medical Technology and Physics, Sir Charles Gairdner Hospital, Nedlands, WA, Australia;2. Medical School, University of Western Australia, Nedlands, Australia;3. Department of Radiology, Beijing Jishuitan Hospital, Beijing, China;4. School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia;5. Mindways Software, Austin, TX, USA |
| |
| Abstract: | Despite the potential roles of sphingosine 1-phosphate (S1P) as a biomarker of osteoporotic fracture (OF), independent of bone mineral density (BMD) and clinical risk factors (CRFs), its association with bone microarchitecture, a key determinant of bone quality, have not been studied yet. We here investigated the association of S1P with the trabecular bone score (TBS), an index of the bone microarchitecture. The plasma S1P concentrations, TBS, and BMD were measured in the 339 postmenopausal women. The S1P level was inversely correlated with the TBS (γ=–0.096, p=0.049) and BMD at the femur neck (FN-BMD: γ=–0.122, p=0.025) and tended to be inversely correlated the BMD at the total hip (TH-BMD: γ=–0.096, p=0.079), but not at the lumbar spine (LS-BMD). After adjusting for fracture risk assessment tool probabilities of major OF from CRFs, the S1P level was inversely associated with the TBS (β=–0.096, p=0.049) and FN-BMD (β=–0.118, p=0.025) and tended to be inversely associated with the TH-BMD (β=–0.092, p=0.083). Compared with subjects in the lowest S1P tertile, those in the highest S1P tertile had a significantly lower TBS (p=0.032) and BMD at femur (p=0.004–0.036). These findings indicated that a high S1P level in postmenopausal women was inversely associated with the both bone mass and microarchitecture, reflecting the compromised bone strength. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
