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Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes |
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| Authors: | Lynn E. Macdonald Margaret Karow Sean Stevens Wojtek Auerbach William T. Poueymirou Jason Yasenchak David Frendewey David M. Valenzuela Cosmas C. Giallourakis Frederick W. Alt George D. Yancopoulos Andrew J. Murphy |
| Affiliation: | aRegeneron Pharmaceuticals, Inc., Tarrytown, NY, 10591;;bGastrointestinal Unit, Massachusetts General Hospital, Boston, MA, 02115;;cThe Howard Hughes Medical Institute, The Children''s Hospital, Boston, MA, 02115; and;dThe Immune Disease Institute and the Department of Genetics, Harvard Medical School, Boston, MA, 02115 |
| Abstract: | |
| Keywords: | genome engineering therapeutic antibody immunoglobulin locus |