Yttrium-90 Radioembolization in the VX2 Rabbit Model: Radiation Safety and Factors Influencing Delivery Efficiency |
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| Affiliation: | 1. Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois;2. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois;3. Department of Radiology, Division of Vascular & Interventional Radiology, Vanderbilt University Medical Center, Vanderbilt University Medical Center, Nashville, Tennessee;5. Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois;6. Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois |
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| Abstract: | The purpose of this study was to define the optimal infusion parameters and operator radiation exposure for yttrium-90 (90Y) radioembolization in the VX2 rabbit model of liver cancer. Forty-one rabbits with VX2 were treated with glass microspheres with vial sizes of 1, 3, and 5 GBq. The mean administered activity was 51.5 MBq (95% CI, 39.1–63.9). Delivery efficiency improved with 1 GBq versus with 3 GBq (residual 11.0% vs 46.4%, respectively; P = .0013) and improved with 1 GBq versus with 5 GBq (residual 11.0% vs 33.8%, respectively; P = .0060). The mean operator extremity exposure was 41.7 μSv/infusion. The optimal minimum infusion volume and rate was 49 mL and 21 mL/min, respectively. Fecal elimination occurred with microsphere uptake in the gallbladder at 1 and 2 weeks. 90Y radioembolization can be safely and efficiently performed in the VX2 rabbit model. Methodological considerations as a “how-to” for the setup of a preclinical 90Y laboratory are included to support future translational research. |
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| Keywords: | MR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0015" }," $$" :[{" #name" :" text" ," _" :" magnetic resonance Yttrium-90 |
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