Fine structure of fetal rat calvarium; provisional identification of preosteoclasts |
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Authors: | Barry R Rifkin John S Brand Janet E Cushing Stephen J Coleman Farshid Sanavi |
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Institution: | (1) Departments of Pathology, Radiation Biology and Biophysics, and Dental Research, University of Rochester School of Medicine and Dentistry, 14642 Rochester, New York, USA |
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Abstract: | Summary This is a study of the fine structure of cells of the 20-day fetal rat calvarium. Special attention is given to identifying
and characterizing preosteoclasts. These cells are relatively common and located largely, but not exclusively, at the endocranial
bone surface. The preosteoclasts are characterized by abundant mitochondria, an incomplete perinuclear Golgi apparatus, and
variable-shaped dense granules. The dense granules are unique in appearance in that they contain an internal dense matrix
surrounded by a clear halo. Most granules are circular in shape but some are elongate or tubular in form. Granules with identical
appearance are observed in osteoclasts. The preosteoclasts are mononucleate, or occasionally binucleate. It is suggested that
because preosteoclasts are morphologically distinctive and relatively abundant, it should be feasible to separate these cells
from a heterogeneous cell isolate. |
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Keywords: | Rat Calvarium Electron microscopy Preosteoclasts Osteoclasts |
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