哮喘患者血一氧化氮含量与肺通气功能的相关性研究

目的：研究哮喘患者血一氧化氮（NO）含量增高与其气道口有气道反应性之间的相互关系。方法：对21例哮喘患者分别测定急性发作期和缓解期血NO含量及1秒钟用力呼气容积（FEV1）、1秒钟用力呼气容积占预计值比例（FEV1％），最大呼气流量（PEF）、最大通气量／1秒用力肺活量比（MVV／FEV1）。结果：（1）哮喘急性发作期血NO含量显著高于缓解期；（2）急性发作期哮喘病人血NO增高与FEV1、FEV1％、PEF呈显著相关性性。结论：哮喘患者急性发作期血NO含量增高与其气道阻塞有关，但与哮喘气道高反应性无明显关系。

RELATIONSHIP BETWEEN NITRIC OXIDE IN BLOOD AND VENTILATIVE FUNCTION OF ASTMATIC PATIENTS

Objective: To study the relationship between the level of nitric oxide(NO) in blood and the ventilative function of asthmatic patients. Method: It was measured the level of NO in blood and forced expiratory volume in one second(FEV 1), ratio of FEV 1 to expected volume(FEV 1%), peak expiratory flow(PEF) and ratio of maximal voluntary ventilation to FEV 1(MVV/FEV 1) of 21 asthmatic patients during acute attack and remission. Result: The level of NO in blood of these patients during acute attack was significantly higher than that during remission. The increased NO was significant correlation with FEV 1,FEV 1% and PEF, and was not correlation with MVV/EFV 1. Conclusion: The increased NO during acute attack is relative to obstruction of respiratory tract, but not to high reaction of respiratory tract.